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Titolo:
PLASMA KALLIKREIN CLEARANCE BY THE LIVER OF CHRONIC CARBON TETRACHLORIDE-TREATED RATS
Autore:
TOLEDO CF; KOUYOUMDJIAN M; LANZONI VP; BORGES DR;
Indirizzi:
ESCOLA PAULISTA MED,DIV GASTROENTEROL,CAIXA POSTAL 20239 BR-04034970 SAO PAULO BRAZIL ESCOLA PAULISTA MED,DIV GASTROENTEROL BR-04034970 SAO PAULO BRAZIL ESCOLA PAULISTA MED,DIV BIOCHEM BR-04034970 SAO PAULO BRAZIL ESCOLA PAULISTA MED,DEPT PATHOL BR-04034970 SAO PAULO BRAZIL
Titolo Testata:
Journal of gastroenterology and hepatology
fascicolo: 2, volume: 10, anno: 1995,
pagine: 165 - 168
SICI:
0815-9319(1995)10:2<165:PKCBTL>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC-CLEARANCE;
Keywords:
ACUTE-PHASE; CIRRHOSIS; ENDOCYTOSIS; KALLIKREIN; LIVER; LIVER INJURY; TETRACHLORIDE-TREATED; TOXIC-HEPATITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
C.F. Toledo et al., "PLASMA KALLIKREIN CLEARANCE BY THE LIVER OF CHRONIC CARBON TETRACHLORIDE-TREATED RATS", Journal of gastroenterology and hepatology, 10(2), 1995, pp. 165-168

Abstract

We have previously reported that the endocytosis of rat plasma kallikrein (RPK) by hepatocytes is a calcium-independent and beta-galactoside-dependent mechanism. We now report the clearance of RPK by the liverof four groups of rats: normal, inflamed (48 h ex-turpentine) and twogroups chronically treated with CCl4 (52 mg/kg per week, intragastrically, for 9-12 weeks). Each liver was isolated, exsanguinated and perfused at 37 degrees C with 30 mL of BSA-Krebs-Henseleit-bicarbonate medium containing 10 nmol/L RPK. Although all rats received the same mildCCl4 treatment, the liver histology showed that they evolved either to severe hepatitis (serum alanine aminotransferase [ALT] 4852 +/- 885 U/L, parenchymatous necrosis in the perivenous region) or to compensated cirrhosis (serum ALT 209 +/- 42 U/L, vigorous fibrous encircling regeneration nodules); neither jaundice nor ascites was noted. The results show that serum albumin was not altered among the groups and that: the acute-phase response by itself (inflamed group) increased RPK clearance rate (3.01 +/- 0.59 mL/min) as compared with the normal group (1.85 +/- 0.14 mL/min); the CCl4 treatment, although induced an acute-phase response, decreased (P < 0.01) RPK clearance rates (0.80 +/- 0.11 mL/min hepatitis group and 0.98 +/- 0.10 mL/min cirrhosis group). These findings suggest that the hepatic clearance rate of plasma kallikrein is an early indicator of liver injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/02/20 alle ore 05:01:22