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Titolo:
EFFECT OF EXERCISE TRAINING ON ANTIOXIDANT SYSTEM IN BRAIN-REGIONS OFRAT
Autore:
SOMANI SM; RAVI R; RYBAK LP;
Indirizzi:
SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL,POB 19230 SPRINGFIELD IL 62794 SO ILLINOIS UNIV,SCH MED,DEPT SURG SPRINGFIELD IL 62794
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 50, anno: 1995,
pagine: 635 - 639
SICI:
0091-3057(1995)50:4<635:EOETOA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE DISULFIDE; STRESS; HEART; MITOCHONDRIA;
Keywords:
EXERCISE; BRAIN REGIONS; SUPEROXIDE DISMUTASE; GLUTATHIONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Somani et al., "EFFECT OF EXERCISE TRAINING ON ANTIOXIDANT SYSTEM IN BRAIN-REGIONS OFRAT", Pharmacology, biochemistry and behavior, 50(4), 1995, pp. 635-639

Abstract

The purpose of this investigation was to determine whether any alterations in antioxidant enzyme activities and levels of glutathione (GSH)in brain regions occurred following exercise training. Sprague-Dawleyrats were given exercise training on a treadmill for 7.5 weeks and sacrificed 18 h after the last exercise along with the sedentary controlrats. Different brain regions-cerebral cortex (CC), brainstem (BS), corpus striatum (CS), and hippocampus (H)-were isolated; GSH, oxidized glutathione (GSSG), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were determined. The exercise training increased SOD activity significantly (130% of sedentary control) in BS and inCS. SOD activity in H was the lowest of all four brain regions. Different brain regions showed GSH-Px activity in decreasing order for CS <BS < CC < H. GSH levels were 43% less in BS than CC and CS. The ratioof GSH/GSSG significantly increased from 6.8 to 8.3 in CC, and from 9.4 to 13.5 in BS as a result of exercise training. Different brain regions contained different activities of antioxidant enzymes, as well asGSH and GSSG levels, which were preferentially altered as a result ofexercise training to cope with oxidative stress.

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Documento generato il 27/09/20 alle ore 00:35:14