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Titolo:
EFFECT OF MEFENOREX ON 5-HT RELEASE - STUDIES IN-VITRO ON RAT HYPOTHALAMIC SLICES AND IN-VIVO BY MICRODIALYSIS
Autore:
OROSCO M; MORET C; BRILEY M; NICOLAIDIS S;
Indirizzi:
COLL FRANCE,CNRS,URA 1860,11 PL MARCELIN BERTHELOT F-75231 PARIS 05 FRANCE CTR RECH PIERRE FABRE F-81106 CASTRES FRANCE
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 50, anno: 1995,
pagine: 485 - 490
SICI:
0091-3057(1995)50:4<485:EOMO5R>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HYDROXYINDOLEACETIC ACID; UPTAKE INHIBITORS; SEROTONIN; 5-HYDROXYTRYPTAMINE; BRAIN; FENFLURAMINE; INVITRO; INVIVO; AMPHETAMINE; MECHANISMS;
Keywords:
MEFENOREX; ANOREXIGENIC DRUG; SEROTONIN; HYPOTHALAMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Orosco et al., "EFFECT OF MEFENOREX ON 5-HT RELEASE - STUDIES IN-VITRO ON RAT HYPOTHALAMIC SLICES AND IN-VIVO BY MICRODIALYSIS", Pharmacology, biochemistry and behavior, 50(4), 1995, pp. 485-490

Abstract

Mefenorex, used for 20 years as an anorexic drug, has not been studied so far with regard to its central mechanism of action, although its chemical structure suggests a serotonergic mechanism. In the present study, the effect of mefenorex on serotonin (5-HT) release was investigated both in vitro, on rat hypothalamic slices and in vive, using microdialysis in the paraventricular (PVN)-ventromedian (VMH) hypothalamicarea while mefenorex was applied locally by means of counterdialysis. In vitro, mefenorex increased the spontaneous release of H-3 5-HT from hypothalamic slices but not the electrically evoked release. This suggests a 5-HT releasing action of mefenorex not mediated through the terminal autoreceptor. The in vive study confirmed the enhanced releaseand provided additional information. The delayed and modest increase of the 5-HT intracellular metabolite 5-HIAA may be indicative of an inhibition of reuptake. The dopaminergic system was also, but more modestly, activated by mefenorex. The increase in 5-HT release together with the inhibition of its reuptake may represent the main mechanism of action of mefenorex, and the secondary activation of the dopaminergic system may contribute in its anorexigenic effect at the level of the PVN-VMH area.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:20:31