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Titolo:
URINARY 17-ALPHA-HYDROXYPROGESTERONE IN MANAGEMENT OF 21-HYDROXYLASE DEFICIENCY
Autore:
LIM YJ; YONG ABW; WARNE GL; MONTALTO J;
Indirizzi:
ROYAL CHILDRENS HOSP,DEPT CLIN BIOCHEM,FLEMINGTON RD PARKVILLE VIC 3052 AUSTRALIA ROYAL CHILDRENS HOSP,DEPT CLIN BIOCHEM,FLEMINGTON RD PARKVILLE VIC 3052 AUSTRALIA ROYAL CHILDRENS HOSP,CTR HORMONE RES PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Journal of paediatrics and child health
fascicolo: 1, volume: 31, anno: 1995,
pagine: 47 - 50
SICI:
1034-4810(1995)31:1<47:U1IMO2>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENITAL ADRENAL-HYPERPLASIA; DIAGNOSIS;
Keywords:
CONGENITAL ADRENAL HYPERPLASIA; 21-HYDROXYLASE DEFICIENCY; URINE 17-OHP; URINE PREGNANETRIOL; SERUM 17-OHP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
Y.J. Lim et al., "URINARY 17-ALPHA-HYDROXYPROGESTERONE IN MANAGEMENT OF 21-HYDROXYLASE DEFICIENCY", Journal of paediatrics and child health, 31(1), 1995, pp. 47-50

Abstract

Objectives: The study was designed to assess the reliability of measurement of 24-hour urinary 17alpha-hydroxyprogesterone (17-OHP) by radio-immunoassay (RIA) as an alternative biochemical assessment for monitoring the treatment of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) and to assess the need for sample purification by column chromatography to improve assay specificity. Methodology: Morning serum 17-OHP was measured using RIA and 24-hour urinarypregnanetriol using gas chromatography. Twenty-four-hour urinary 17-OHP was measured in samples from 17 prepubertal patients with CAH due to 21-OHD, and 20 normal prepubertal children as controls. In 24 urine samples, RIA of 17-OHP was performed with and without column chromatography. Results: There was a good correlation between 24-hour urinary 17-OHP and 24-hour urinary pregnanetriol (r = 0.962, P<0.01) and between 24-hour urinary 17-OHP and morning serum 17-OHP (r = 0.955, P<0.01). There was no significant difference in the RIA of the urine samples with and without purification by column chromatography. Conclusions: The measurement of 24-hour urinary 17-OHP is a reliable alternative for the biochemical monitoring of 21-OHD, and RIA specificity is unaffected by omission of column chromatography.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 04:24:45