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Titolo:
PRIMARY INTRACEREBRAL MALIGNANT-LYMPHOMA - A CLINICOPATHOLOGICAL STUDY OF 89 PATIENTS
Autore:
TOMLINSON FH; KURTIN PJ; SUMAN VJ; SCHEITHAUER BW; OFALLON JR; KELLY PJ; JACK CR; ONEILL BP;
Indirizzi:
MAYO CLIN & MAYO FDN,DEPT NEUROL,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT NEUROL ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT NEUROL SURG ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT LAB MED & PATHOL ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT HLTH SCI RES,BIOSTAT SECT ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT DIAGNOST RADIOL ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,CTR COMPREHENS CANC,CANC STAT UNIT ROCHESTER MN 55905
Titolo Testata:
Journal of neurosurgery
fascicolo: 4, volume: 82, anno: 1995,
pagine: 558 - 566
SICI:
0022-3085(1995)82:4<558:PIM-AC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; NON-HODGKINS-LYMPHOMA; PRIMARY CNS LYMPHOMA; PRIMARY INTRACRANIAL LYMPHOMA; RADIATION-THERAPY; BRAIN; CHEMOTHERAPY; SURVIVAL; PATTERNS; CANCER;
Keywords:
PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA; BRAIN NEOPLASM; NON-HODGKINS LYMPHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
F.H. Tomlinson et al., "PRIMARY INTRACEREBRAL MALIGNANT-LYMPHOMA - A CLINICOPATHOLOGICAL STUDY OF 89 PATIENTS", Journal of neurosurgery, 82(4), 1995, pp. 558-566

Abstract

The authors report on a clinicopathological study of 89 surgical patients with histologically proven primary parenchymal brain lymphoma, all diagnosed between January 1975 and December 1990. The cohort included 60 men and 29 women whose median age at diagnosis was 60 years (range 14 to 84 years). The duration of symptoms was less than 8 weeks in 48% of the patients. Symptom groups included focal neurological deficit(73%), neuropsychiatric symptoms (28%), seizures (9%), and increased intracranial pressure (3%). A total of 132 tumors were seen in 89 patients: the most common sites were frontal (32 patients), temporoparietal (31 patients), and basal ganglia (17 patients); multiple lesions were reported in 23 patients. No patient had antecedent of human immunodeficiency virus positivity or acquired immunodeficiency syndrome. A family history of cancer was present in 33% of the patients, three-quarters of whom were first-degree relatives. Histological subtypes (National Cancer Institute Working Formulation) included 64 large cell (72%) and 13 immunoblastic (15%) tumors. Phenotype was determined in 66 patients: 63 were B-cell type and three were T-cell type. Surgical resection was performed in 47% of the cases, with the remainder undergoing biopsy only. All but six patients received radiation therapy. Thirty-one patients received chemotherapy, whereas 46 patients did not; data on the remaining 12 patients were unavailable. The end point of the study was death from any cause. At the time of last contact, 69 of the patients (78%) had died; the median survival time for this study group was 20.9 months. On univariate analysis, prognostic factors significantly associated with survival included age at diagnosis, family history of cancer, and focal neurological deficit. Multivariate analysis revealedfour unfavorable prognostic factors: age greater than or equal to 60 years, history of cancer in first-degree relatives, focal deficit, andependymal contact. After adjustment for these variables, clinical syndrome, size and number of lesions, extent of surgery, histological cell type, radiation dose, and use of chemotherapy were not significantlyassociated with survival.

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Documento generato il 26/11/20 alle ore 09:02:24