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Titolo:
STRESS-INDUCED BEHAVIORAL-RESPONSES AND MULTIPLE OPIOID SYSTEMS IN THE BRAIN
Autore:
YAMADA K; NABESHIMA T;
Indirizzi:
NAGOYA UNIV,SCH MED,DEPT NEUROPSYCHOPHARMACOL & HOSP PHARM,SHOWA KU NAGOYA AICHI 466 JAPAN NAGOYA UNIV,SCH MED,DEPT NEUROPSYCHOPHARMACOL & HOSP PHARM,SHOWA KU NAGOYA AICHI 466 JAPAN
Titolo Testata:
Behavioural brain research
fascicolo: 2, volume: 67, anno: 1995,
pagine: 133 - 145
SICI:
0166-4328(1995)67:2<133:SBAMOS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOTSHOCK-INDUCED ANALGESIA; CORTICOTROPIN-RELEASING-FACTOR; LEARNED CONDITIONED-SUPPRESSION; DYNORPHIN-A 1-17; COLD-WATER SWIM; CENTRAL-NERVOUS-SYSTEM; GUINEA-PIG BRAIN; REPEATED ELECTROCONVULSIVE SHOCKS; MORPHINE-INDUCED ANTINOCICEPTION; INTRAVENTRICULAR BETA-ENDORPHIN;
Keywords:
STRESS; STRESS-INDUCED ANALGESIA; MOTOR SUPPRESSION; CONDITIONED FEAR STRESS; OPIOID PEPTIDE; KAPPA-OPIOID RECEPTOR; MU-OPIOID RECEPTOR; DELTA-OPIOID RECEPTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
231
Recensione:
Indirizzi per estratti:
Citazione:
K. Yamada e T. Nabeshima, "STRESS-INDUCED BEHAVIORAL-RESPONSES AND MULTIPLE OPIOID SYSTEMS IN THE BRAIN", Behavioural brain research, 67(2), 1995, pp. 133-145

Abstract

Various stressor produce a wide range of behavioral responses such asanalgesia, catalepsy and motor suppression, which are sensitive to opioid receptor antagonists. These behavioral responses in stress are accompanied by changes in the contents of opioid peptides, the mRNAs encoding their precursors and opioid receptor binding in the brain. In the present article, experimental data concerning stress-induced analgesia and motor suppression is reviewed and discussed in relation to a possible involvement of different opioid systems in the various observedbehavioral responses in stress. Pharmacological studies with subtype-selective antagonists have demonstrated that not only mu- but also delta- and/or kappa-opioid receptors are involved in opioid-mediated stress-induced analgesia. There are two types of stress-induced analgesia referred to as opioid-mediated and non-opioid mediated forms. It has been proposed that the intensity and temporal pattern of stressor may be a critical factor determining the nature of stress-induced analgesia. Accumulated evidence demonstrate that these two foms of pain inhibitory systems interact each other according to a collateral inhibition model. Recent studies show that parallel activation of multiple opioid receptors mediates non-opioid froms of stress-induced analgesia. Dynorphins, by acting at kappa-opioid receptors, may play a pivotal role inthe expression of stress-induced motor suppression, whereas enkephalins may act to attenuate this response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:13:19