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Titolo:
SELECTIVE PROSTAGLANDIN D-2 RECEPTOR STIMULATION ELICITS OCULAR HYPOTENSIVE EFFECTS IN RABBITS AND CATS
Autore:
MATSUGI T; KAGEYAMA M; NISHIMURA K; GILES H; SHIRASAWA E;
Indirizzi:
SANTEN PHARMACEUT CO LTD,DEV RES LABS,HIGASHIYODOGAWA KU,3-9-19 SHIMOSHINJO OSAKA 533 JAPAN WELLCOME RES LABS BECKENHAM BR3 3BS KENT ENGLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 275, anno: 1995,
pagine: 245 - 250
SICI:
0014-2999(1995)275:3<245:SPDRSE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAOCULAR-PRESSURE; DP-RECEPTORS; PROSTANOID RECEPTORS; CLASSIFICATION; BW-A868C; ANTAGONIST; PLATELET; PGD2; PHARMACOLOGY; RESPONSES;
Keywords:
DP RECEPTOR; 572C85; BW A868C; INTRAOCULAR PRESSURE; (RABBIT); (CAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
T. Matsugi et al., "SELECTIVE PROSTAGLANDIN D-2 RECEPTOR STIMULATION ELICITS OCULAR HYPOTENSIVE EFFECTS IN RABBITS AND CATS", European journal of pharmacology, 275(3), 1995, pp. 245-250

Abstract

The effects of the selective prostaglandin D-2 (DP) receptor agonists, 572C85 yl-amino)hexahydrocyclopenta(d)imidazol-2(1H)-one) and 192C86)-3-ethylhexahydrocyclopenta(d)imidazol-2(1H)-one, were determined onintraocular pressure regulation in rabbits and cats. 572C85 (50 mu g)in rabbits maximally lowered intraocular pressure by 4.3 mm Hg, and significantly for 4 h compared to control. In cats 572C85 had a similareffect. 192C86 (50 mu g) reduced intraocular pressure by 2.8 mm Hg for 2 h in rabbits. Following exposure to the specific DP receptor antagonist, BW A868C l)-1-(2-cyclohexyl-2-hydroxyethylamino)-hydantoin; 50 mu g), which had no effect on intraocular pressure by itself, 572C85 (50 mu g) did not reduce intraocular pressure in rabbits and cats. The intraocular pressure lowering effect of the mixed DP and EP receptor agonist, BW245C yhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)-hydantoin 50 mu g), in cats was suppressed by only 64% by BW A868C (50 mu g). These results clearly show that the DP receptors in rabbit and cat eyes are involved in intraocular pressure regulation. However, under baseline conditions DP receptor activity does not contribute to this regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:01:21