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Titolo:
UNILATERAL TRIGEMINAL NERVE BRANCH LESION (V1 AND V2) AT THE SKULL BASE AND NASAL CAPSULE GROWTH IN RABBITS
Autore:
SKEDROS DG; MOONEY MP; SIEGEL MI; LOSKEN A; SMITH TD; JANECKA IP;
Indirizzi:
UNIV PITTSBURGH,DEPT ANAT & HISTOL,631 SALK HALL PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT ANAT & HISTOL PITTSBURGH PA 15261
Titolo Testata:
The Journal of craniofacial surgery
fascicolo: 1, volume: 6, anno: 1995,
pagine: 40 - 48
SICI:
1049-2275(1995)6:1<40:UTNBL(>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Keywords:
TRIGEMINAL NERVE LESION; SKULL BASE SURGERY; NASAL CAPSULE; MIDFACIAL GROWTH; NEUROTROPHISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
D.G. Skedros et al., "UNILATERAL TRIGEMINAL NERVE BRANCH LESION (V1 AND V2) AT THE SKULL BASE AND NASAL CAPSULE GROWTH IN RABBITS", The Journal of craniofacial surgery, 6(1), 1995, pp. 40-48

Abstract

The effects of long-term afferent denervation on midfacial and nasal capsule growth after craniofacial or skull base surgery are unknown. Experimental studies suggest that afferent nerves may play a role in regulating craniofacial growth through neurotrophic influences. The present study was designed to assess the effects of nasal capsule afferent(V1 and V2) denervation on nasal capsule growth in the rabbit. Eighteen 11/2-week-old rabbits were evenly divided into three groups: unoperated controls, sham controls, and animals with unilateral anterior ethmoid and sphenopalatine nerve lesions. The nerves were lesioned at theskull base with electrocautery through an intraorbital approach at 11/2 weeks of age. Lateral head radiographs and dental study models weretaken at 11/2, 31/2, 6, and 12 weeks of age. By 31/2 weeks of age, sham controls and animals with nerve lesions exhibited significant(p < 0.05) reductions in nasal capsule area and height compared with unoperated control animals; the lesioned animals were more severely affected. However, by 6 weeks no differences were noted between the sham and lesioned groups, which were both smaller than unoperated controls through 12 weeks of age. Results suggest that acute nasal capsule growth deficits are a consequence of surgery as well as afferent denervation, with a greater deficit in the latter group, possibly through neurotrophic interruption. Such deficits may not be a permanent effect in the rabbit model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:51:19