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Titolo:
NUMA - A PROTEIN INVOLVED IN NUCLEAR-STRUCTURE, SPINDLE ASSEMBLY, ANDNUCLEAR RE-FORMATION
Autore:
CLEVELAND DW;
Indirizzi:
UNIV CALIF SAN DIEGO,LUDWIG INST,9500 GILMAN DR LA JOLLA CA 92093
Titolo Testata:
Trends in cell biology
fascicolo: 2, volume: 5, anno: 1995,
pagine: 60 - 64
SICI:
0962-8924(1995)5:2<60:N-APII>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOTIC APPARATUS PROTEIN; MONOCLONAL-ANTIBODY; SPN ANTIGEN; PTK2 CELLS; MITOSIS; MATRIX; MICROINJECTION; IDENTIFICATION; COMPLETION; FRAMEWORK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
D.W. Cleveland, "NUMA - A PROTEIN INVOLVED IN NUCLEAR-STRUCTURE, SPINDLE ASSEMBLY, ANDNUCLEAR RE-FORMATION", Trends in cell biology, 5(2), 1995, pp. 60-64

Abstract

The abundant coiled-coil protein NuMA is located in the nucleus during interphase, but when the nuclear envelope disassembles in prometaphase it rapidly redistributes to the developing spindle poles. Microinjection of antibodies to NuMA at or before metaphase can block spindle function. NuMA must also play a key role in telophase, as NuMA antibodies or truncations of NuMA cause aberrant nuclear reassembly despite apparently normal chromosome segregation. Consistent with a structural role for NuMA in the nucleus, immunoelectron microscopy reveals NuMA tobe a component of nuclear filaments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 10:57:05