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Titolo:
DEVELOPMENTAL SEQUENCE OF BONE-RESORBING CELLS INDUCED BY INTRAMUSCULAR IMPLANTATION OF MINERAL-CONTAINING BONE PARTICLES INTO RAINBOW-TROUT, ONCORHYNCHUS-MYKISS
Autore:
TAKAGI Y; KANEKO T;
Indirizzi:
UNIV TOKYO,OTSUCHI MARINE RES CTR,OCEAN RES INST OTSUCHI IWATE 02811 JAPAN UNIV TOKYO,OCEAN RES INST TOKYO 164 JAPAN
Titolo Testata:
Cell and tissue research
fascicolo: 1, volume: 280, anno: 1995,
pagine: 153 - 158
SICI:
0302-766X(1995)280:1<153:DSOBCI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MONOCYTES; OSTEOCLASTS; RESORPTION; INVITRO; FISH;
Keywords:
OSTEOCLASTS; BONE RESORPTION; ACID PHOSPHATASE; CAPILLARY NETWORK; RAINBOW TROUT, ONCORHYNCHUS MYKISS (TELEOSTEI);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takagi e T. Kaneko, "DEVELOPMENTAL SEQUENCE OF BONE-RESORBING CELLS INDUCED BY INTRAMUSCULAR IMPLANTATION OF MINERAL-CONTAINING BONE PARTICLES INTO RAINBOW-TROUT, ONCORHYNCHUS-MYKISS", Cell and tissue research, 280(1), 1995, pp. 153-158

Abstract

Mineral-containing bone particles (BPs) were implanted intramuscularly into rainbow trout (Oncorhynchus mykiss) to investigate the sequenceof appearance of bone-resorbing cells. A fibrous substance first surrounded the implanted BPs and was gradually replaced by connective tissue containing capillaries. Two weeks after BP implantation, relativelysmall multinucleated cells (type-1 cells), whose cytoplasm stained deeply with hematoxylin, appeared along the surfaces of the BPs. At later stages (after 4-8 weeks), the majority of cells which appeared to beresorbing the BPs were multinucleated cells whose cytoplasm stained deeply with eosin (type-2 cells). Type-2 cells contained more nuclei than type-1 cells. Electron-microscopical observations revealed that type-2 cells had the characteristic features of osteoclasts: the presenceof numerous mitochondria, vacuoles and granules, and a differentiation of the cell membrane and cytoplasm into a ruffled border and clear zone, respectively. A tartrate-resistant acid phosphatase activity, which is an established characteristic of osteoclasts in terrestrial vertebrates, but which had not previously been examined in teleosts, was demonstrated histochemically in the type-2 cells. Development of type-2cells was closely correlated with the development of connective tissue. These findings suggest that the development of a capillary network around the implanted BPs enables circulating osteoclast-progenitors toreach the surface of the BPs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:18:58