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Titolo:
CONTINUOUS MONITORING OF ENERGY METABOLITES USING MICRODIALYSIS DURING MYOCARDIAL-ISCHEMIA IN THE PIG
Autore:
WIKSTROM G; RONQUIST G; NILSSON S; MARIPU E; WALDENSTROM A;
Indirizzi:
UNIV UPPSALA HOSP,DEPT CARDIOL S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT CARDIOL S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT CLIN CHEM S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT DIAGNOST RADIOL S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT RADIOPHYS S-75185 UPPSALA SWEDEN
Titolo Testata:
European heart journal
fascicolo: 3, volume: 16, anno: 1995,
pagine: 339 - 347
SICI:
0195-668X(1995)16:3<339:CMOEMU>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY OCCLUSION; CARDIAC MICRODIALYSIS; CANINE HEART; BLOOD-FLOW; ADENOSINE; ISCHEMIA; INJURY; RAT;
Keywords:
HEART; MICRODIALYSIS; MICROSPHERES; INFARCTION; ADENOSINE; NUCLEOSIDES; LACTATE; PYRUVATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
G. Wikstrom et al., "CONTINUOUS MONITORING OF ENERGY METABOLITES USING MICRODIALYSIS DURING MYOCARDIAL-ISCHEMIA IN THE PIG", European heart journal, 16(3), 1995, pp. 339-347

Abstract

A diagonal branch of rite left anterior descending artery was occluded for 80 min. One microdialysis probe was inserted in the ischaemic area and two in the non-ischaemic areas. In six animals radiolabelled microspheres were injected before and during ischaemia and after reperfusion to monitor flow. Arterial and pulmonary artery pressures, pulmonary capillary wedge pressure and cardiac output 1 were followed-up. Radiolabelled microsphere distribution confirmed the reduction of myocardial blood flow during coronary artery occlusion, with flow returning to normal values upon reperfusion. Rate pressure product as an index ofheart work was stable throughout the 80 min ischaemic period, but increased at reperfusion. Dialysates from non-ischaemic tissue showed stable baseline values. In ischaemic tissue, lactate increased by 300% and pyruvate levels decreased by 50% within 15 min. Adenosine increased rapidly five-fold, but started to decline after 15 min of ischaemia. Inosine showed a slower but a marked 20-fold increase, decreasing at the end of the ischaemic period. Hypoxanthine increased five-fold duringthe first 30 min. Finally guanosine showed a slow increase to about four times above basic values. Microdialysis was an excellent tool for the continuous monitoring of myocardial metabolites during ischaemia. Adenosine appeared to be a more sensitive marker of early ischaemia than lactate, although interestingly, adenosine levels had decreased already after 15 min, mast probably due to intracellular accumulation of protons and Pi.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:00:08