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Titolo:
AP5 BLOCKS LTP IN DEVELOPING RAT DENTATE GYRUS AND UNMASKS LTD
Autore:
TROMMER BL; KENNELLY JJ; COLLEY PA; OVERSTREET LS; SLATER NT; PASTERNAK JF;
Indirizzi:
EVANSTON HOSP CORP,DEPT PEDIAT,DIV NEUROL EVANSTON IL 00000 NORTHWESTERN UNIV,SCH MED,DEPT PEDIAT & NEUROL CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT PHYSIOL CHICAGO IL 60611
Titolo Testata:
Experimental neurology
fascicolo: 1, volume: 131, anno: 1995,
pagine: 83 - 92
SICI:
0014-4886(1995)131:1<83:ABLIDR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; METHYL-D-ASPARTATE; RABBIT FOLLOWING STIMULATION; RECEPTOR ANTAGONISTS BLOCK; NMDA RECEPTOR; LASTING POTENTIATION; SYNAPTIC TRANSMISSION; HIPPOCAMPAL-FORMATION; POSTNATAL-DEVELOPMENT; STRIATE CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Trommer et al., "AP5 BLOCKS LTP IN DEVELOPING RAT DENTATE GYRUS AND UNMASKS LTD", Experimental neurology, 131(1), 1995, pp. 83-92

Abstract

The hippocampal dentate gyrus undergoes active neuronogenesis as wellas growth and regression of neuronal elements and connections during the early postnatal period. In some brain regions, most notably in thevisual system, both activity-dependent synaptic plasticity and NMDA receptor activation are candidate mechanisms by which neuronal architecture may be refined during brain maturation. To investigate whether similar mechanisms might obtain in developing dentate, we studied the effects of tetanic stimulation before and after NMDA receptor blockade in hippocampal slices from rats at 7-33 days. Field potentials were recorded in the suprapyramidal granule cell layer in response to stimulation of the medial perforant path. Robust long-term potentiation (LTP) of population spike amplitude (similar to 200% of baseline) was produced by a single tetanus (100 Hz, 2 s, 200 mu s) at all ages studied. Application of 10 mu M AP5 depressed population spike amplitude only in the younger slices (similar to 81% of baseline at 8-15 days; similar to 86% of baseline at 16-24 days), suggesting that the NMDA receptor-mediated component of normal synaptic transmission is higher in early development and decreases with maturation. AP5 prevented or significantly diminished LTP at all ages, establishing the NMDA dependence of LTP induction in the medial perforant path throughout development. AP5 also unmasked tetanus-induced homosynaptic long-term depression (62-75% of baseline) in the younger slices (8-24 days). Thus, prominent NMDA receptor-mediated activity and the capacity for bidirectional synaptic plasticity are characteristic of immature dentate. These processes may influence dentate morphogenesis by contributing to the growth, regression, and stabilization of neuronal elements. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:33:55