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Titolo:
A RANDOMIZED, CROSSOVER EVALUATION OF METHYLPHENIDATE IN CANCER-PATIENTS RECEIVING STRONG NARCOTICS
Autore:
WILWERDING MB; LOPRINZI CL; MAILLIARD JA; OFALLON JR; MISER AW; VANHAELST C; BARTON DL; FOLEY JF; ATHMANN LM;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV MED ONCOL,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DIV MED ONCOL ROCHESTER MN 55905 CREIGHTON UNIV,UNIV NEBRASKA MED CTR & ASSOCIATES,NEBRASKA ONCOL GRP OMAHA NE 68131 MAYO CLIN & MAYO FDN,CTR CANC,STAT UNIT ROCHESTER MN 55905 CARLE CANC CTR,COMMUNITY CLIN ONCOL PROGRAM URBANA IL 61801 DULUTH COMMUNITY CLIN ONCOL PROGRAM DULUTH MN 55805
Titolo Testata:
Supportive care in cancer
fascicolo: 2, volume: 3, anno: 1995,
pagine: 135 - 138
SICI:
0941-4355(1995)3:2<135:ARCEOM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIN;
Keywords:
METHYLPHENIDATE; NARCOTIC-INDUCED SEDATION; PSYCHOSTIMULANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Wilwerding et al., "A RANDOMIZED, CROSSOVER EVALUATION OF METHYLPHENIDATE IN CANCER-PATIENTS RECEIVING STRONG NARCOTICS", Supportive care in cancer, 3(2), 1995, pp. 135-138

Abstract

Sedation may be a dose limiting side-effect of opioid therapy in somecancer patients. This study was designed to evaluate further the use of the psychostimulant, methylphenidate, an agent that has been reported to counteract opioid-induced sedation, in patients with cancer-related pain. Patients receiving a stable dose of an opioid for cancer-related pain were recruited for this randomized, double-blind, crossover clinical trial. In addition to their regular dose of narcotics, they received 5 days of methylphenidate followed by 5 days of placebo, or vice versa. Our data did not definitively demonstrate any statistically significant benefit for methylphenidate, but did suggest that this drug could mildly decrease narcotic-induced drowsiness and could increasenight-time sleep. These data, in conjunction with other published data, suggest that methylphenidate can counteract narcotic-induced daytime sedation to a limited degree.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:05:47