Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CLEARANCE OF HIV-INFECTION IN A PERINATALLY INFECTED INFANT
Autore:
BRYSON YJ; PANG S; WEI LS; DICKOVER R; DIAGNE A; CHEN ISY;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT PEDIAT,DIV INFECT DIS LOS ANGELESCA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT UROL LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT MED LOS ANGELES CA 90024
Titolo Testata:
The New England journal of medicine
fascicolo: 13, volume: 332, anno: 1995,
pagine: 833 - 838
SICI:
0028-4793(1995)332:13<833:COHIAP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; SERONEGATIVE HOMOSEXUAL MEN; POLYMERASE CHAIN-REACTION; ANTIBODY-PRODUCTION; TYPE-1 INFECTION; BRAIN-TISSUE; DRUG-ABUSERS; CHILDREN; RESPONSES; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
Y.J. Bryson et al., "CLEARANCE OF HIV-INFECTION IN A PERINATALLY INFECTED INFANT", The New England journal of medicine, 332(13), 1995, pp. 833-838

Abstract

Background. We describe a child who was identified shortly after birth as infected with the human immunodeficiency virus type 1 (HIV-1), but whose infection appears to have completely cleared. Asymptomatic HIV-1 infection was diagnosed in the mother during the fourth month of pregnancy. The infant was delivered vaginally at 36 weeks, received no blood products, and was not breast-fed. Methods and Results. HIV-1 was detected by culture of the infant's peripheral-blood mononuclear cellsat 19 and 51 days of age. Plasma from the infant was also culture-positive for HIV-1 at 51 days of age by DNA polymerase chain reaction (PCR). Nucleotide-sequence analysis of HIV-1 DNA showed extremely close homology of the cultures obtained 32 days apart, and forensic markers of genetic identity for the two cultures were identical. Hence, inadvertent viral contamination or error in the collection of specimens was highly unlikely. At 12 months of age the infant was seronegative for HIV-1, and numerous subsequent cultures and tests by PCR have also been negative for HIV-1. The child is five years of age at this writing, isHIV-seronegative, and remains well, with normal growth and development and no laboratory or clinical evidence of HIV-1 infection. Conclusions. The infant we describe was infected perinatally with HIV-1, but the infection subsequently cleared and the infant remained without detectable HIV-1 infection five years later.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:42:10