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Titolo:
ARACHIDONIC-ACID MAY MEDIATE THE GALANIN-INDUCED HYPERPOLARIZATION INPARASYMPATHETIC NEURONS FROM NECTURUS-MACULOSUS
Autore:
MULVANEY JM; PARSONS RL;
Indirizzi:
UNIV VERMONT,COLL MED,DEPT ANAT & NEUROBIOL BURLINGTON VT 05405
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 187, anno: 1995,
pagine: 95 - 98
SICI:
0304-3940(1995)187:2<95:AMMTGH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITORS; PEPTIDE;
Keywords:
ARACHIDONIC ACID; GALANIN; MUDPUPPY; PARASYMPATHETIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Mulvaney e R.L. Parsons, "ARACHIDONIC-ACID MAY MEDIATE THE GALANIN-INDUCED HYPERPOLARIZATION INPARASYMPATHETIC NEURONS FROM NECTURUS-MACULOSUS", Neuroscience letters, 187(2), 1995, pp. 95-98

Abstract

The effects of arachidonic acid (AA) and compounds that inhibit intracellular signalling pathways on membrane potential and galanin-inducedhyperpolarizations were investigated in parasympathetic neurons from Necturus maculosus. Treatment for 10-90 min with 10-20 mu M 4-bromophenacylbromide or 10 mu M cyclosporin A caused a progressive decrease inthe amplitude of galanin-induced hyperpolarizations without any change in resting membrane potential. The galanin-induced hyperpolarizationwas not altered following a 10-120 min treatment with the protein kinase inhibitor H-7. These results indicated that phospholipase Az activation, but not protein kinase activation, may be required for the galanin-induced hyperpolarization. Arachidonic acid (20-100 mu M) caused aconcentration-dependent membrane hyperpolarization of the parasympathetic neurons and a decrease in the amplitude of the galanin-induced hyperpolarization. These data indicate that phospholipase A(2)-catalyzedliberation of AA may be involved in the galanin-induced membrane hyperpolarization observed in mudpuppy parasympathetic neurons.

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Documento generato il 04/12/20 alle ore 12:54:38