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Titolo:
REGIONAL CEREBRAL METABOLISM OF GLUCOSE IN COMATOSE AND VEGETATIVE STATE PATIENTS
Autore:
TOMMASINO C; GRANA C; LUCIGNANI G; TORRI G; FAZIO F;
Indirizzi:
H SAN RAFFAELE,INST SCI,DEPT ANESTHESIA,VIA OLGETTINA 60 I-20132 MILAN ITALY UNIV MILAN,DEPT ANESTHESIOL & INTENS CARE I-20122 MILAN ITALY CNR,INB,DEPT NUCL MED I-20133 MILAN ITALY
Titolo Testata:
Journal of neurosurgical anesthesiology
fascicolo: 2, volume: 7, anno: 1995,
pagine: 109 - 116
SICI:
0898-4921(1995)7:2<109:RCMOGI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; HEAD-INJURY; BRAIN; PET; ATROPHY; MR;
Keywords:
BRAIN METABOLISM OF GLUCOSE, REGIONAL; POSITRON EMISSION TOMOGRAPHY; TRAUM; CARDIAC ARREST; COMA; FDG (2-[F-18]-FLUORO-2-DEOXY-D-GLUCOSE); VEGETATIVE STATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
C. Tommasino et al., "REGIONAL CEREBRAL METABOLISM OF GLUCOSE IN COMATOSE AND VEGETATIVE STATE PATIENTS", Journal of neurosurgical anesthesiology, 7(2), 1995, pp. 109-116

Abstract

Regional cerebral metabolism of glucose (rCMR(glu)) was evaluated in patients who were in a coma and vegetative state to determine the level of brain function during these conditions. rCMR(glu) was measured in17 discrete brain regions with 2-[F-18]-fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET) in 15 patients with brain pathology subsequent to cardiorespiratory arrest (CA), head trauma (HT), or brain ischemia (BI) resulting from cerebrovascular accident or brain surgery. Five comatose patients (Coma group, n = 5), and 10 vegetative state patients (VS, patients awake but not aware) were studied. TheVS patients were subdivided, according to the length of their VS condition, into a VS group (n = 6, <3 months if CA or BI patients, or <12 months if HT patients) and a persistent vegetative state group (PVS, n= 4, >3 months if CA or BI patients or >12 months if HT patients). Ten normal age-matched subjects served as control. Global CMR(glu) was 6.72 +/- 0.93 (+/- SD) mg/100 g/min in control subjects. It was significantly (p less-than-or-equal-to 0.001) reduced to 3.70 +/- 61 in coma,to 3.45 +/- 0.78 in VS, and to 2.33 +/- 0.34 mg/100 g/min in PVS patients. rCMR(glu) was significantly reduced (p less-than-or-equal-to 0.001) from control values in all the 17 structures surveyed in every patient. In the Coma and VS groups, there was an overlapping of rCMR(glu)in the majority of the brain structures. The only significant difference was in the occipital lobe, at level of the primary visual cortex, where a higher metabolic rate was found in VS patients (4.08 +/- 0.89 vs. 3.79 +/- 0.63 mg/100 g/min, p less-than-or-equal-to 0.001). rCMR(glu) was maximally reduced in PVS patients (range, 50-72%), and the reduction was significantly lower than that of the Coma (range, 36-54%) and VS (range, 34-54%) groups in all the structures (p less-than-or-equal-to 0.001). Global, as well as rCMR(glu), did not correlate with clinical outcome, whereas younger age significantly correlated with recovery of consciousness.

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Documento generato il 19/01/20 alle ore 20:11:23