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Titolo:
KAPPA-OPIOID RECEPTOR-TRANSFECTED CELL-LINES - MODULATION OF ADENYLYL-CYCLASE ACTIVITY FOLLOWING ACUTE AND CHRONIC OPIOID TREATMENTS
Autore:
AVIDORREISS T; ZIPPEL R; LEVY R; SAYA D; EZRA V; BARG J; MATUSLEIBOVITCH N; VOGEL Z;
Indirizzi:
WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL UNIV MILAN,DEPT GEN PHYSIOL & BIOCHEM MILAN ITALY TEL AVIV UNIV,SCH MED,WOLFSON MED CTR,CARDIOVASC & HYPERTENS RES LAB IL-69978 HOLON ISRAEL
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 361, anno: 1995,
pagine: 70 - 74
SICI:
0014-5793(1995)361:1<70:KRC-MO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROBLASTOMA SH-SY5Y CELLS; BINDING;
Keywords:
OPIOID RECEPTOR; FORSKOLIN; ADENYLYL CYCLASE; GTP-BINDING PROTEIN; ADDICTION; WITHDRAWAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
T. Avidorreiss et al., "KAPPA-OPIOID RECEPTOR-TRANSFECTED CELL-LINES - MODULATION OF ADENYLYL-CYCLASE ACTIVITY FOLLOWING ACUTE AND CHRONIC OPIOID TREATMENTS", FEBS letters, 361(1), 1995, pp. 70-74

Abstract

The opioid receptors mu, delta and kappa have recently been cloned. Here me show that kappa-agonists inhibit adenylyl cyclase activity in Chinese hamster ovary cells stably transfected with rat kappa-opioid receptor cDNA. Chronic exposure of the cells to kappa-agonists did not lead to significant desensitization of the capacity of the agonists to inhibit adenylyl cyclase. On the other hand, withdrawal of the agonistfollowing the chronic treatment led to the phenomenon of supersensitivity ('overshoot') of adenylyl cyclase activity. Both the inhibition of adenylyl cyclase activity by the acute opioid treatment and the chronic agonist-induced supersensitivity are pertussis toxin sensitive, demonstrating involvement of G(i)/G(o) proteins in both processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 15:29:42