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Titolo:
THE ROLE OF CD4(-CELLS IN PROTECTIVE IMMUNITY TO THE MURINE NEMATODE PARASITE TRICHURIS-MURIS() AND CD8(+) T)
Autore:
KOYAMA K; TAMAUCHI H; ITO Y;
Indirizzi:
KITASATO UNIV,SCH MED,DEPT PARASITOL,1-15-1 KITASATO SAGAMIHARA KANAGAWA 228 JAPAN KITASATO UNIV,SCH MED,DEPT MICROBIOL SAGAMIHARA KANAGAWA 228 JAPAN
Titolo Testata:
Parasite immunology
fascicolo: 3, volume: 17, anno: 1995,
pagine: 161 - 165
SICI:
0141-9838(1995)17:3<161:TROCIP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; SCHISTOSOMA-MANSONI; CYTOKINE PRODUCTION; TRYPANOSOMA-CRUZI; IFN-GAMMA; INFECTION; MICE; SUSCEPTIBILITY; LYMPHOCYTES; RESISTANCE;
Keywords:
T-MURIS; INTESTINAL NEMATODE PARASITES; CD4(+) T CELLS; CD8(+) T CELLS; ANTI-CD4 TREATMENT; ANTI-CD8 TREATMENT; SPLEENS; MESENTERIC LYMPH NODES; PEYERS PATCHES; MOABS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K. Koyama et al., "THE ROLE OF CD4(-CELLS IN PROTECTIVE IMMUNITY TO THE MURINE NEMATODE PARASITE TRICHURIS-MURIS() AND CD8(+) T)", Parasite immunology, 17(3), 1995, pp. 161-165

Abstract

The role of CD4(+) and CD8(+) T cells in protective immunity to Trichuris muris was studied in CD4(+) or CD8(+) or bath CD4(+) and CD8(+) Tcell-depleted BALB/c mice. To assess in vivo depletion of T-cell subsets, CD4(+) and CD8(+) T cells in the Peyer's patches, the mesenteric lymph nodes (MLN), and the spleens of mice treated with T cell-specific monoclonal antibodies (MoAbs) were analysed by FACS. CD4(+) T cells were selectively depleted in mice injected with anti-CD4 MoAb i.p. andinjection of anti-CD8 MoAb resulted in selective depletion of CD8(+) T cells. The expulsion of T. muris was inhibited in CD4(+) T cell-depleted mice and numerous worms were detected in the large intestine on days 14 and 21 after infection, although no suppression of protective immunity to T. muris was observed in CD8(+) T cell-depleted mice. Moreover, there was no difference in suppression of protective immunity to T. muris between CD4(+) T cell-depleted and both CD4(+) and CD8(+) T cell-depleted mice. These results indicate that CD4(+) T cells play a central role in protective immunity to T. muris infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:44:11