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Titolo:
REGULATION OF SPEMANN ORGANIZER FORMATION BY THE INTRACELLULAR KINASEXGSK-3
Autore:
PIERCE SB; KIMELMAN D;
Indirizzi:
UNIV WASHINGTON,DEPT BIOCHEM,SJ-70 SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOCHEM SEATTLE WA 98195
Titolo Testata:
Development
fascicolo: 3, volume: 121, anno: 1995,
pagine: 755 - 765
SICI:
0950-1991(1995)121:3<755:ROSOFB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOGEN-SYNTHASE KINASE-3; EARLY AMPHIBIAN EMBRYO; XENOPUS-LAEVIS EMBRYOS; JUNCTIONAL COMMUNICATION; WINGLESS PROTEIN; MESODERM INDUCER; NEURAL INDUCTION; UV IRRADIATION; GROWTH-FACTOR; DROSOPHILA;
Keywords:
XENOPUS; SPEMANN ORGANIZER; KINASE XGSK-3; DORSAL AXIS FORMATION; WNT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Pierce e D. Kimelman, "REGULATION OF SPEMANN ORGANIZER FORMATION BY THE INTRACELLULAR KINASEXGSK-3", Development, 121(3), 1995, pp. 755-765

Abstract

Dorsal axis formation in the Xenopus embryo can be induced by the ectopic expression of several Wnt family members. In Drosophila, the protein encoded by the Wnt family gene, wingless, signals through a pathway that antagonizes the effects of the serine/threonine kinase zeste-white 3/shaggy. We describe the isolation and characterization of a Xenopus homolog of zeste-white 3/shaggy, Xgsk-3. A kinase-dead mutant of Xgsk-3, Xgsk-3K-->R, has a dominant negative effect and mimics the ability of Wnt to induce a secondary axis by induction of an ectopic Spemann organizer. Xgsk-3K-->R, like Wnt, induces dorsal axis formation when expressed in the deep vegetal cells, which do not contribute to the axis. These results indicate that the dorsal fate is actively repressed by Xgsk-3, which must be inactivated for dorsal axis formation to occur. Furthermore, our work suggests that the effects of Xgsk-3K-->R are mediated by an additional intercellular signal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 20:16:27