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Titolo:
SEGMENTAL INTESTINAL TRANSPLANTATION CAN BE AN ADEQUATE THERAPY FOR SHORT-BOWEL SYNDROME IN GROWING DOGS
Autore:
WOLVEKAMP MCJ; HEINEMAN E; MARQUET RL; MEIJSSEN MAC; DEBRUIN RWF; MOLENAAR JC;
Indirizzi:
ACAD HOSP MAASTRICHT,DEPT SURG,POB 5800 6202 AZ MAASTRICHT NETHERLANDS ACAD HOSP MAASTRICHT,DEPT SURG 6202 AZ MAASTRICHT NETHERLANDS ERASMUS UNIV HOSP,DEPT PEDIAT SURG ROTTERDAM NETHERLANDS ERASMUS UNIV HOSP,DEPT GEN SURG ROTTERDAM NETHERLANDS ERASMUS UNIV HOSP,DEPT INTERNAL MED 2 ROTTERDAM NETHERLANDS
Titolo Testata:
Journal of pediatric surgery
fascicolo: 3, volume: 30, anno: 1995,
pagine: 396 - 401
SICI:
0022-3468(1995)30:3<396:SITCBA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA DIAMINE OXIDASE; RAT; AUTOTRANSPLANTS; TRANSLOCATION; SURVIVAL; URINARY; SERUM;
Keywords:
SEGMENTAL INTESTINAL TRANSPLANTATION; SHORT BOWEL SYNDROME; GROWING DOGS; CYCLOSPORINE A IMMUNOSUPPRESSION; SELECTIVE DIGESTIVE TRACT DECONTAMINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M.C.J. Wolvekamp et al., "SEGMENTAL INTESTINAL TRANSPLANTATION CAN BE AN ADEQUATE THERAPY FOR SHORT-BOWEL SYNDROME IN GROWING DOGS", Journal of pediatric surgery, 30(3), 1995, pp. 396-401

Abstract

This study was undertaken to investigate whether two stage segmental small bowel allotransplantation can maintain growth and development ofyoung dogs (16 weeks, 5 to 6kg) with surgically created short bowel syndrome (SBS). After near-total small bowel resection (group 1; n = 3), irreversible weight loss was noted. After a sham operation (group 2;n = 3), no growth disturbances were found. Major histocompatibility matched small bowel transplantation (SET) with cyclosporine A as immunosuppressant, was performed in two stages (group 3; n = 7). During the first stage, one meter of jejunoileum from an adult donor was placed as a Roux loop. Four weeks later, the native small bowel was removed and replaced by the graft. Only one dog survived long-term; the dogs died from infectious complications. The addition of selective decontamination of the digestive tract and early gastrostomy feeding (group 4; n = 10) resulted in long term survival in 60%. Follow-up at 4 months showed that their growth was about 20% compromised compared with that of the sham-operated animals. Functional analysis showed that electrolytes, urea, and D-xylose were normal, but there was an increase in the lactulose:mannitol ratio, fecal fat excretion, and postheparin diamine oxidase release. These results show that under the conditions described, segmental SET functions sufficiently to treat SBS but does not maintain normal growth. Copyright (C) 1995 by W.B. Saunders Company

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:26:07