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Titolo:
INTERLEUKIN-9 AND ITS RECEPTOR - INVOLVEMENT IN MAST-CELL DIFFERENTIATION AND T-CELL ONCOGENESIS
Autore:
RENAULD JC; KERMOUNI A; VINK A; LOUAHED J; VANSNICK J;
Indirizzi:
LUDWIG INST CANC RES,AVE HIPPOCRATE 74 B-1200 BRUSSELS BELGIUM UNIV CATHOLIQUE LOUVAIN,EXPTL MED UNIT B-1200 BRUSSELS BELGIUM
Titolo Testata:
Journal of leukocyte biology
fascicolo: 3, volume: 57, anno: 1995,
pagine: 353 - 360
SICI:
0741-5400(1995)57:3<353:IAIR-I>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-ENHANCING ACTIVITY; NECROSIS FACTOR-ALPHA; INSITU HYBRIDIZATION; PROTECTIVE IMMUNITY; RESPONSE PHENOTYPES; EXPRESSION CLONING; PROGENITOR CELLS; COLONY FORMATION; GENE-EXPRESSION; IL-9 EXPRESSION;
Keywords:
CYTOKINES; T LYMPHOCYTES; MAST CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Renauld et al., "INTERLEUKIN-9 AND ITS RECEPTOR - INVOLVEMENT IN MAST-CELL DIFFERENTIATION AND T-CELL ONCOGENESIS", Journal of leukocyte biology, 57(3), 1995, pp. 353-360

Abstract

Interleukin-9 (IL-9) is a multifunctional cytokine produced by activated TH2 clones in vitro and during TH2-like T cell responses in vivo. The IL-9 receptor is a member of the hemopoietin receptor superfamily and interacts with the gamma chain of the IL-2 receptor for signal transduction. Various observations indicate that IL-9 is actively involved in mast cell responses by inducing the proliferation and differentiation of these cells, The role of IL-9 in T cell responses is less clear. Although freshly isolated normal T cells do not respond to IL-9, this cytokine induces the proliferation of murine T cell lymphomas in vitro and in vivo overexpression of IL-9 results in the development of thymic lymphomas. In the human, the existence of an IL-9-mediated autocrine loop has been suggested for some malignancies such as Hodgkin's disease. Other potential biological targets for IL-9 include B lymphocytes, hematopoietic progenitors, and immature neuronal cell lines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 09:53:23