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Titolo:
SKELETAL-MUSCLE FIBER COMPOSITION IS RELATED TO ADIPOSITY AND IN-VITRO GLUCOSE-TRANSPORT RATE IN HUMANS
Autore:
HICKEY MS; CAREY JO; AZEVEDO JL; HOUMARD JA; PORIES WJ; ISRAEL RG; DOHM GL;
Indirizzi:
E CAROLINA UNIV,SCH HLTH & HUMAN PERFORMANCE,HUMAN PERFORMANCE LAB,371 SPORTS MED BLDG GREENVILLE NC 27858 E CAROLINA UNIV,SCH MED,DEPT SURG GREENVILLE NC 27858 E CAROLINA UNIV,SCH MED,DEPT BIOCHEM GREENVILLE NC 27858
Titolo Testata:
American journal of physiology: endocrinology and metabolism
fascicolo: 3, volume: 31, anno: 1995,
pagine: 453 - 457
SICI:
0193-1849(1995)31:3<453:SFCIRT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN RESISTANCE; BODY-WEIGHT; OBESITY; INVIVO; METABOLISM; STIMULATION; TOLERANCE; GLYCOGEN; BINDING; GLUT-4;
Keywords:
INSULIN RESISTANCE; MORBID OBESITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Hickey et al., "SKELETAL-MUSCLE FIBER COMPOSITION IS RELATED TO ADIPOSITY AND IN-VITRO GLUCOSE-TRANSPORT RATE IN HUMANS", American journal of physiology: endocrinology and metabolism, 31(3), 1995, pp. 453-457

Abstract

The purpose of this study was to determine if a relationship exists among skeletal muscle fiber composition, adiposity, and in vitro muscleglucose transport rate in humans. Rectus abdominus muscle was obtained during elective abdominal surgery from nonobese control(n = 12), obese (n = 12), and obese non-insulin-dependent diabetes mellitus (NIDDM)patients (n = 10). The obese NIDDM group had a significantly lower percentage of type I muscle fibers (32.2 +/- 1.9%) than the obese group (40.4 +/- 2.7%), and both obese groups were significantly lower than the control group (50.0 +/- 2.6%). Insulin-stimulated glucose transport, determined on 28 subjects, was significantly lower in both the obese(3.83 +/- 0.48 nmol . min(-1). mg(-1)) and NIDDM (3.93 +/- 1.0 nmol .min(-1). mg(-1)) groups vs. the control group (7.35 +/- 1.50 nmol . min(-1). mg(-1)). Body mass index (BMI) was inversely correlated to percent type I fibers (r = -0.50, P < 0.01) and to the insulin-stimulatedglucose transport rate (r = -0.53, P < 0.01), The percentage of type I muscle fibers was related to the insulin-stimulated glucose transport rate (r = 0.57, P < 0.01), although this relationship was not significant after adjusting for BMI. Although these data do not support an independent relationship between fiber type and insulin action in obesity, a reduced skeletal muscle type I fiber population may be one component of a multifactorial process involved in the development of insulin resistance.

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Documento generato il 27/11/20 alle ore 00:10:04