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Titolo:
TETANICALLY INDUCED LTP INVOLVES A SIMILAR INCREASE IN THE AMPA AND NMDA RECEPTOR COMPONENTS OF THE EXCITATORY POSTSYNAPTIC CURRENT - INVESTIGATIONS OF THE INVOLVEMENT OF MGLU RECEPTORS
Autore:
OCONNOR JJ; ROWAN MJ; ANWYL R;
Indirizzi:
UNIV DUBLIN TRINITY COLL,DEPT PHARMACOL & THERAPEUT DUBLIN 2 IRELAND UNIV DUBLIN TRINITY COLL,DEPT PHARMACOL & THERAPEUT DUBLIN 2 IRELAND UNIV DUBLIN TRINITY COLL,DEPT PHYSIOL DUBLIN 2 IRELAND
Titolo Testata:
The Journal of neuroscience
fascicolo: 3, volume: 15, anno: 1995,
parte:, 1
pagine: 2013 - 2020
SICI:
0270-6474(1995)15:3<2013:TILIAS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; METABOTROPIC GLUTAMATE RECEPTORS; PROTEIN-KINASE-C; HIPPOCAMPAL CA1 NEURONS; SPINAL DORSAL HORN; SYNAPTIC TRANSMISSION; TRANS-ACPD; INDUCTION; RESPONSES; SLICES;
Keywords:
1S,3R-ACPD (1-AMINO-CYCLOPENTANE-1,3-DICARBOXYLIC ACID); LONG-TERM POTENTIATION; EXCITATORY POSTSYNAPTIC CURRENTS; AMPA RECEPTORS; NMDA RECEPTORS; METABOTROPIC GLUTAMATE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Oconnor et al., "TETANICALLY INDUCED LTP INVOLVES A SIMILAR INCREASE IN THE AMPA AND NMDA RECEPTOR COMPONENTS OF THE EXCITATORY POSTSYNAPTIC CURRENT - INVESTIGATIONS OF THE INVOLVEMENT OF MGLU RECEPTORS", The Journal of neuroscience, 15(3), 1995, pp. 2013-2020

Abstract

Whole-cell patch-clamp recordings of evoked excitatory postsynaptic currents (EPSCs) were made from granule cells of the rat dentate gyrus in vitro. Tetanic stimulation in control media evoked a statistically identical long-term potentiation (LTP) of both the AMPA and NMDA receptor-mediated components of the dual component EPSC (AMPAR and NMDAR EPSCs), as shown by a similar percentage increase in both components when measured at a holding potential of -30 mV, and also by an identical time course of the pre- and post-LTP induced EPSC at -30 mV and -70 mV. Application of the selective metabotropic glutamate receptor (mGluR)agonist 1S,3R-ACPD induced a transient depression followed by a rapidonset LTP of both the AMPAR and the NMDAR components of the dual component EPSC. The ACPD- and tetanically induced LTP of the AMPAR EPSC was NMDAR dependent, being abolished by the NMDAR antagonist AP5. Tetanic stimulation, and application of ACPD, also induced a relatively rapid onset LTP of the pharmacologically isolated NMDAR EPSC. Such tetanically and ACPD-induced LTP of the isolated NMDAR EPSC was also dependent on NMDAR activation, being strongly inhibited by AP5. The tetanically and the ACPD-induced LTP of the NMDAR EPSC were dependent on proteinkinase C (PKC) stimulation, being strongly inhibited by the PKC inhibitor PKCl (19-31). The studies suggest that coactivation of the mGluR and NMDAR are required for induction of LTP of both the AMPAR- and NMDAR-mediated synaptic transmission. Moreover, LTP of the NMDAR-mediatedsynaptic transmission appears to be dependent on coincident activation of the NMDAR and mGluR.

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Documento generato il 11/07/20 alle ore 07:31:37