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Titolo:
THE MORPHOELECTROTONIC TRANSFORM - A GRAPHICAL APPROACH TO DENDRITIC FUNCTION
Autore:
ZADOR AM; AGMONSNIR H; SEGEV I;
Indirizzi:
SALK INST BIOL STUDIES,MNL S,10010 N TORREY PINES RD LA JOLLA CA 92037 HEBREW UNIV JERUSALEM,DEPT NEUROBIOL IL-91904 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,CTR NEURAL COMPUTAT,INST LIFE SCI IL-91904 JERUSALEM ISRAEL SALK INST BIOL STUDIES,MNL S LA JOLLA CA 92037
Titolo Testata:
The Journal of neuroscience
fascicolo: 3, volume: 15, anno: 1995,
parte:, 1
pagine: 1669 - 1682
SICI:
0270-6474(1995)15:3<1669:TMT-AG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ARBITRARY GEOMETRY; GUINEA-PIG; SPINES; CALCIUM; MOTONEURONS; MECHANISM; RESPONSES; NEURONS; INPUT;
Keywords:
COMPUTER MODELS; ELECTROTONIC STRUCTURE; DENDRITIC COMPUTATION; CABLE THEORY; CALCIUM DYNAMICS; DENDRITIC SPINES; NEURONAL SIMULATION; DENDRITIC MORPHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Zador et al., "THE MORPHOELECTROTONIC TRANSFORM - A GRAPHICAL APPROACH TO DENDRITIC FUNCTION", The Journal of neuroscience, 15(3), 1995, pp. 1669-1682

Abstract

Electrotonic structure of dendrites plays a critical role in neuronalcomputation and plasticity, In this article we develop two novel measures of electrotonic structure that describe intraneuronal signaling in dendrites of arbitrary geometry. The log-attenuation L(ij) measures the efficacy, and the propagation delay P-ij the speed, of signal transfer between any two points i and j. These measures are additive, in the sense that if j lies between i and k, the total distance L(ik) is just the sum of the partial distances: L(ik) = L(ij) + L(jk), and similarly P-ik = P-ij + P-jk. This property serves as the basis for the morphoelectrotonic transform (MET), a graphical mapping from morphological into electrotonic space. In a MET, either P-ij or L(ij) replace anatomical distance as the fundamental unit and so provide direct functional measures of intraneuronal signaling. The analysis holds for arbitrary transient signals, even those generated by nonlinear conductance changes underlying both synaptic and action potentials. Depending on input location and the measure of interest, a single neuron admits many METs, each emphasizing different functional consequences of the dendritic electrotonic structure. Using a single layer 5 cortical pyramidal neuron, we illustrate a collection of METs that lead to a deeper understanding of the electrical behavior of its dendritic tree. We then compare this cortical cell to representative neurons from other brain regions (cortical layer 2/3 pyramidal, region CA1 hippocampal pyramidal, and cerebellar Purkinje). Finally, we apply the MET to electrical signaling in dendritic spines, and extend this analysis to calcium signaling within spines. Our results demonstrate that the MET provides a powerful tool for obtaining a rapid and intuitive grasp of the functional properties of dendritic trees.

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Documento generato il 07/07/20 alle ore 11:43:38