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Titolo:
ADJUVANTICITY OF ISCOMS INCORPORATING A T-CELL-REACTIVE LIPOPROTEIN OF THE FACULTATIVE INTRACELLULAR PATHOGEN FRANCISELLA-TULARENSIS
Autore:
GOLOVLIOV I; ERICSSON M; AKERBLOM L; SANDSTROM G; TARNVIK A; SJOSTEDT A;
Indirizzi:
UMEA UNIV,DEPT INFECT DIS S-90187 UMEA SWEDEN UMEA UNIV,DEPT INFECT DIS S-90187 UMEA SWEDEN NATL DEF RES ESTAB,DEPT MICROBIOL S-90182 UMEA SWEDEN LYUBUCHANY IMMUNOL INST LYUBUCHANY 142380 RUSSIA FAC VET UPPSALA,DEPT VIROL S-75123 UPPSALA SWEDEN NATL VET INST S-75123 UPPSALA SWEDEN
Titolo Testata:
Vaccine
fascicolo: 3, volume: 13, anno: 1995,
pagine: 261 - 267
SICI:
0264-410X(1995)13:3<261:AOIIAT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVE VACCINE STRAIN; MEMBRANE-PROTEINS; ANTIGENIC PRESENTATION; PROTECTIVE IMMUNITY; MEDIATED-IMMUNITY; INTERFERON-GAMMA; MICE; VIRUS; TULAREMIA; INFECTION;
Keywords:
FRANCISELLA TULARENSIS LVS; IMMUNE RESPONSE; IMMUNOSTIMULATING COMPLEXES; GAMMA-INTERFERON; LIPOPROTEIN; T CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
I. Golovliov et al., "ADJUVANTICITY OF ISCOMS INCORPORATING A T-CELL-REACTIVE LIPOPROTEIN OF THE FACULTATIVE INTRACELLULAR PATHOGEN FRANCISELLA-TULARENSIS", Vaccine, 13(3), 1995, pp. 261-267

Abstract

Immunostimulating complexes (ISCOMs) are known to be highly effectiveadjuvants for envelope antigens of viral agents, but have not been evaluated for use with antigens of intracellular bacteria. Balb/c mice were subcutaneously immunized with ISCOMs into which the T cell-reactive membrane protein TUL4 of Francisella tularensis had been incorporated. Spleen cells from the immunized mice responded in vitro to TUL4 andto heat-killed F. tularensis live vaccine strain (LVS) with proliferation and production of gamma-interferon, whereas spleen cells from control mice immunized with TUL4 only did not respond to the antigens. When mice immunized with TUL4 ISCOMs, were challenged with F. tularensisLVS, bacterial counts in spleen and liver were lower than in non-immunized mice. Again, TUL4 had no effect when used without ISCOMs. When proteins of a total membrane preparation of F. tularensis LVS were incorporated in ISCOMs and used for immunization, a decrease in bacterial counts was obtained which was similar in magnitude to that of TUL4 ISCOMs. Generally, the adjuvant effects demonstrated did not compare withthe excellent protective effect of live tularaemia vaccine, Nonetheless, ISCOMs provide a means whereby protective antigens of F. tularensis can be tested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 04:17:16