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Titolo:
ANGIOTENSIN-II DECREASES INDUCIBLE NITRIC-OXIDE SYNTHASE EXPRESSION IN RAT ASTROGLIAL CULTURES
Autore:
CHANDLER LJ; KOPNISKY K; RICHARDS E; CREWS FT; SUMNERS C;
Indirizzi:
LOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL,BOX 100267,1501 KINGS HIGHWAY SHREVEPORT LA 71130 UNIV FLORIDA,COLL MED,DEPT PHARMACOL GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,DEPT PHYSIOL GAINESVILLE FL 32610
Titolo Testata:
American journal of physiology. Cell physiology
fascicolo: 3, volume: 37, anno: 1995,
pagine: 700 - 707
SICI:
0363-6143(1995)37:3<700:ADINSE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION MECHANISMS; CENTRAL-NERVOUS-SYSTEM; GLIAL-CELLS; BACTERIAL LIPOPOLYSACCHARIDE; RECEPTOR SUBTYPES; NADPH-DIAPHORASE; BINDING-SITES; BRAIN; ASTROCYTES; INDUCTION;
Keywords:
ANGIOTENSIN II TYPE 1 RECEPTOR; LIPOPOLYSACCHARIDE; CYTOKINES; ASTROGLIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
L.J. Chandler et al., "ANGIOTENSIN-II DECREASES INDUCIBLE NITRIC-OXIDE SYNTHASE EXPRESSION IN RAT ASTROGLIAL CULTURES", American journal of physiology. Cell physiology, 37(3), 1995, pp. 700-707

Abstract

Consistent with stimulation of expression of an inducible form of nitric oxide synthase (iNOS), exposure of rat astroglial cultures to lipopolysaccharide (LPS) caused a time-dependent increase in the accumulation of nitrite in the culture media. Addition of the peptide angiotensin II (ANG II) with LPS decreased subsequent formation of nitrite in aconcentration-dependent manner (concentration inhibiting 50% of maximal response similar to 1 nM). The ANG II effect could be blocked by the ANG II type 1 (AT(1)) receptor antagonist losartan but not by the ANG II type 2 (AT(2)) receptor antagonist PD-123177. ANG II had no effect on nitrite formation stimulated by a combination of inflammatory cytokines (interleukin-1 beta, tumor necrosis factor-alpha, and interferon-gamma). A brief 10-min exposure to ANG II was sufficient to cause ansimilar to 30% inhibition of the LPS response, with maximal inhibition of similar to 65% after 3 h, and occurred only when ANG II was addedduring the iNOS induction phase. Consistent with partial inhibition of LPS-stimulated expression of iNOS, ANG II reduced the levels of bothiNOS mRNA and iNOS protein. These results demonstrate that ANG II candecrease LPS-stimulated NO production in astroglia by inhibiting induction of iNOS expression.

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Documento generato il 02/12/20 alle ore 17:49:04