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Titolo:
CARDIAC MALFORMATION IN NEONATAL MICE LACKING CONNEXIN43
Autore:
REAUME AG; DESOUSA PA; KULKARNI S; LANGILLE BL; ZHU DG; DAVIES TC; JUNEJA SC; KIDDER GM; ROSSANT J;
Indirizzi:
MT SINAI HOSP,SAMUEL LUNENFELD RES INST,600 UNIV AVE TORONTO ON M5G 1X5 CANADA MT SINAI HOSP,SAMUEL LUNENFELD RES INST TORONTO ON M5G 1X5 CANADA UNIV TORONTO,DEPT MOLEC & MED GENET TORONTO ON M5S 1A8 CANADA UNIV WESTERN ONTARIO,DEPT ZOOL LONDON ON N6A 5B7 CANADA UNIV WESTERN ONTARIO,MOLEC GENET UNIT LONDON ON N6A 5B7 CANADA MAX BELL RES CTR,TORONTO GEN DIV TORONTO ON M5G 2C4 CANADA UNIV TORONTO,DEPT PATHOL TORONTO ON M5S 1A8 CANADA
Titolo Testata:
Science
fascicolo: 5205, volume: 267, anno: 1995,
pagine: 1831 - 1834
SICI:
0036-8075(1995)267:5205<1831:CMINML>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAP JUNCTION PROTEIN; MOUSE PREIMPLANTATION EMBRYOS; RAT-HEART; EXPRESSION; COMMUNICATION; CELLS; CHICK; MYOCARDIUM; PREGNANCY; TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
A.G. Reaume et al., "CARDIAC MALFORMATION IN NEONATAL MICE LACKING CONNEXIN43", Science, 267(5205), 1995, pp. 1831-1834

Abstract

Gap junctions are made up of connexin proteins, which comprise a multigene family in mammals. Targeted mutagenesis of connexin43 (Cx43), one of the most prevalent connexin proteins, showed that its absence wascompatible with survival of mouse embryos to term, even though mutantcell lines showed reduced dye coupling in vitro. However, mutant embryos died at birth, as a result of a failure in pulmonary gas exchange caused by a swelling and blockage of the right ventricular outflow tract from the heart. This finding suggests that Cx43 plays an essential role in heart development but that there is functional compensation among connexins in other parts of the developing fetus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 08:20:58