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Titolo:
CONTROL OF ENDOMETRIAL OXYTOCIN RECEPTORS AND PROSTAGLANDIN-F2-ALPHA PRODUCTION IN COWS BY PROGESTERONE AND ESTRADIOL
Autore:
LAMMING GE; MANN GE;
Indirizzi:
UNIV NOTTINGHAM,DEPT PHYSIOL & ENVIRONM SCI LOUGHBOROUGH LE12 5RD LEICS ENGLAND
Titolo Testata:
Journal of Reproduction and Fertility
fascicolo: 1, volume: 103, anno: 1995,
pagine: 69 - 73
SICI:
0022-4251(1995)103:1<69:COEORA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVINE UTERUS; HORMONE; LUTEOLYSIS; SECRETION; ESTROGEN; EWES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
G.E. Lamming e G.E. Mann, "CONTROL OF ENDOMETRIAL OXYTOCIN RECEPTORS AND PROSTAGLANDIN-F2-ALPHA PRODUCTION IN COWS BY PROGESTERONE AND ESTRADIOL", Journal of Reproduction and Fertility, 103(1), 1995, pp. 69-73

Abstract

We have investigated changes in endometrial oxytocin receptor concentrations and prostaglandin F-2 alpha release in response to exogenous oxytocin treatment in ovariectomized cows treated with progesterone andoestradiol, and made comparisons with similar treatment in cyclic cows. In long-term ovariectomized cows, endometrial oxytocin receptors were present (300 fmol mg(-1) protein), but no prostaglandin F-2 alpha was released in response to oxytocin treatment until after the administration of progesterone. Subsequent administration of a concentration of oestradiol sufficient to induce oestrus resulted in the downregulation of these receptors and the loss of oxytocin responsiveness, which did not reappear within 20 days in the absence of further hormone treatment. When induced oestrus was followed by further treatment with luteal phase concentrations of progesterone and oestradiol, both oxytocin receptors and oxytocin-stimulated release of prostaglandin F-2 alpha reappeared by day 16 after oestrus, in a pattern similar to that seen during the luteal phase of cyclic cows. These results demonstrate how progesterone and oestradiol control the development and responsiveness of endometrial oxytocin receptors in cows, and provide a valuable model in which to investigate further the precise control of the oxytocin receptor in this species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:58:34