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Titolo:
SMOOTH-MUSCLE DEVELOPMENT IN THE OBSTRUCTED FETAL BLADDER
Autore:
FREEDMAN AL; QURESHI F; SHAPIRO E; LEPOR H; JACQUES SM; EVANS MI; SMITH CA; GONZALEZ R; JOHNSON MP;
Indirizzi:
CHILDRENS HOSP MICHIGAN,DEPT UROL,3901 BEAUBIEN BLVD DETROIT MI 48201 CHILDRENS HOSP MICHIGAN,DEPT PEDIAT UROL DETROIT MI 00000 WAYNE STATE UNIV,HUTZEL HOSP,CTR FETAL DIAGNOSIS & THERAPY,DEPT OBSTET & GYNECOL DETROIT MI 00000 WAYNE STATE UNIV,HUTZEL HOSP,DEPT PATHOL DETROIT MI 00000 NYU,SCH MED,DEPT UROL NEW YORK NY 00000
Titolo Testata:
Urology
fascicolo: 1, volume: 49, anno: 1997,
pagine: 104 - 107
SICI:
0090-4295(1997)49:1<104:SDITOF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTERIOR URETHRAL VALVES; PRUNE BELLY SYNDROME; RAT URINARY-BLADDER; OUTFLOW OBSTRUCTION; COLLAGEN; ELASTIN; URETER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A.L. Freedman et al., "SMOOTH-MUSCLE DEVELOPMENT IN THE OBSTRUCTED FETAL BLADDER", Urology, 49(1), 1997, pp. 104-107

Abstract

Objectives. To evaluate changes in the smooth muscle and connective tissue development in the obstructed and normal fetal bladder. Methods. The smooth muscle and connective tissue composition of 19 fetal urinary bladders, including those of 9 fetuses with anatomic obstruction and 10 controls free of urologic disease, were analyzed by light microscopy and computer-assisted color image analysis. Results. The bladder wall thickness was markedly increased in obstructed fetuses throughout gestation as compared with that in controls. The disparity in bladder wall thickness increased rapidly during gestation. The percent area density of smooth muscle and connective tissue as well as the ratio of smooth muscle to connective tissue remained the same in the obstructed and normal control fetal bladders. Conclusions. Although bladder outlet obstruction is associated with a marked increase in bladder wall thickness, the percent of smooth muscle and connective tissue comprising the mural histology remains relatively constant as compared with that of normal fetal controls. This study suggests that bladder outlet obstruction in the fetus is not associated with excess collagen depositionbut rather with an increased amount of bladder with normal cellular content and a concomitant increase in smooth muscle development. Copyright 1997 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 22:34:09