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Titolo:
24-HOUR EFFICACY OF 2 DOSE LEVELS OF A ONCE-DAILY SUSTAINED-RELEASE DILTIAZEM FORMULATION IN STABLE ANGINA - A PLACEBO-CONTROLLED TRIAL
Autore:
FRANCES Y; GAGEY S; STALLABOURDILLON A; BADOURALY A; BENKEMOUN P; BINEAU P; BOUSSER JP; CHABANIER A; CHAMPOUD O; CHARLIAGUET JP; DRAWIN T; DUMOULIN P; FRAISSE A; GAUDEUL P; GINESTES J; HENRY M; LARDOUX H; MARTIN M; MORALY JP; ROUFFAUD J; SARDA R; TARDIEU A; YVENOU L; BAUERLEIN G; KIKIS D; SENGES J; DEDEVITIS O; TRIMARCO B;
Indirizzi:
SYNTHELABO RECH,31 AVE PAUL VAILLANT COUTURIER,BP 110 F-92225 BAGNEUXFRANCE SYNTHELABO RECH F-92225 BAGNEUX FRANCE HOP NORD MARSEILLE F-13005 MARSEILLE FRANCE
Titolo Testata:
British journal of clinical pharmacology
fascicolo: 3, volume: 39, anno: 1995,
pagine: 277 - 282
SICI:
0306-5251(1995)39:3<277:2EO2DL>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PECTORIS;
Keywords:
STABLE ANGINA PECTORIS; DILTIAZEM; ONCE DAILY SUSTAINED-RELEASE FORMULATION; EXERCISE TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
Y. Frances et al., "24-HOUR EFFICACY OF 2 DOSE LEVELS OF A ONCE-DAILY SUSTAINED-RELEASE DILTIAZEM FORMULATION IN STABLE ANGINA - A PLACEBO-CONTROLLED TRIAL", British journal of clinical pharmacology, 39(3), 1995, pp. 277-282

Abstract

1 This placebo-controlled study assessed once daily sustained-release(SR) diltiazem, 200 and 300 mg, in 182 stable angina patients with positive exercise test. 2 Exercise testing was performed at baseline after a 7 day placebo run-in period, and repeated after 7 days of treatment, 25.0 +/- 0.1 h postdose. 3 Diltiazem (200 and 300 mg) produced respectively a 68% and a 64% decrease in weekly angina episodes, and placebo a 15% decrease (P < 0.05). Similarly, both dose levels produced a 70% decrease in nitroglycerin consumption, whereas no difference was obtained with placebo (P < 0.01). The increase in time to ischaemic threshold was significantly superior for 200 mg and 300 mg diltiazem whencompared with placebo (75.2 and 91.5 s respectively vs 47.0 s) (P < 0.05); increase in time to anginal threshold was also significantly greater for diltiazem when compared with placebo (84.6 and 85.9 s respectively vs 43.9 s) (P < 0.05). 4 Only one patient experienced worsening of angina and had to be withdrawn from the study. 5 This study demonstrates 200 and 300 mg SR diltiazem is effective when given once-a-day in the prophylaxis of stable exertional angina. This once daily formulation should improve patients' compliance and comfort.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:55:45