Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FOR-MET-LYS-PHE-FOR-MET-LYS-PHE- - A NEW CYCLIC ANALOG OF THE CHEMOTACTIC FORMYLPEPTIDES
Autore:
TORRINI I; ZECCHIN GP; PARADIS MP; LUCENTE G; GAVUZZO E; MAZZA F; POCHETTI G; TRANIELLO S; SPISANI S;
Indirizzi:
UNIV ROMA LA SAPIENZA,DIPARTIMENTO STUDI FARMACEUT I-00185 ROME ITALY UNIV ROMA LA SAPIENZA,CNR,CTR STUDIO CHIM FARMACO I-00185 ROME ITALY CNR,IST STRUTTURIST CHIM G GIACOMELLO I-00016 MONTEROTONDO ITALY UNIV FERRARA,DIPARTIMENTO BIOCHIM & BIOL MOLEC I-44100 FERRARA ITALY
Titolo Testata:
Biopolymers
fascicolo: 4, volume: 35, anno: 1995,
pagine: 347 - 358
SICI:
0006-3525(1995)35:4<347:F-ANCA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIDE-CHAIN; PEPTIDES; CONFORMATION; DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
I. Torrini et al., "FOR-MET-LYS-PHE-FOR-MET-LYS-PHE- - A NEW CYCLIC ANALOG OF THE CHEMOTACTIC FORMYLPEPTIDES", Biopolymers, 35(4), 1995, pp. 347-358

Abstract

As a continuation of the studies of chemotactic N-formylpeptides, we report here the synthesis and activity of a new cyclic analogue of theprototypical ligand For-Met-Leu-Phe-OMe. The new compound For-Met-Lys-Phe-For-Met-Lys-Phe- (4) contains a 20-membered cyclic moiety made upof a dimeric -Lys-Phe- sequence in which For-Met is attached to each Lys alpha-NH2 and hence remains outside the ring. The conformation in the crystal of the cyclic precursor of 4, namely Boc-Lys-Phe-Boc-Lys-Phe- (2) and the activity of the structurally related linear analogue For-Met-Lys(Z)-Phe-Obzl (6), have also been examined. The new analogues4 and 6 are active as chemoattractants, secretagogues, and superoxideanion generating agents, when tested on human neutrophils. The structure-activity relationship is discussed and related to that of a previously studied cyclic mode. (C) 1995 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:03:30