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Titolo:
GENETIC SUSCEPTIBILITY TO MULTIPLE-SCLEROSIS IN A SHANGHAI CHINESE POPULATION - THE ROLE OF THE HLA CLASS-II GENES
Autore:
KELLY MA; ZHANG Y; PENNY MA; JACOBS KH; CAVAN DA; MIJOVIC CH; CHOU KY; BARNETT AH; FRANCIS DA;
Indirizzi:
UNIV BIRMINGHAM,DEPT MED BIRMINGHAM B15 2TH W MIDLANDS ENGLAND UNIV BIRMINGHAM,DEPT MED BIRMINGHAM W MIDLANDS ENGLAND BIRMINGHAM HEARTLANDS HOSP BIRMINGHAM B9 5ST W MIDLANDS ENGLAND SHANGHAI MED UNIV 2,SHANGHAI INST IMMUNOL SHANGHAI PEOPLES R CHINA QUEEN ELIZABETH HOSP,REG CTR NEUROL BIRMINGHAM B15 2TH W MIDLANDS ENGLAND QUEEN ELIZABETH HOSP,UNIV DEPT BIRMINGHAM B15 2TH W MIDLANDS ENGLAND
Titolo Testata:
Human immunology
fascicolo: 3, volume: 42, anno: 1995,
pagine: 203 - 208
SICI:
0198-8859(1995)42:3<203:GSTMIA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HONG-KONG; ANTIGENS; ALLELE; PREVALENCE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Kelly et al., "GENETIC SUSCEPTIBILITY TO MULTIPLE-SCLEROSIS IN A SHANGHAI CHINESE POPULATION - THE ROLE OF THE HLA CLASS-II GENES", Human immunology, 42(3), 1995, pp. 203-208

Abstract

The association of MS with the HLA class II loci DR and DQ was investigated in subjects of Shanghai Chinese and British Caucasian origin. Our aim was to determine whether common alleles predispose to the disease in both races. In the Caucasian population MS was significantly positively associated with the putative haplotype DRB11501, DQA1*0102, DQB10602. In contrast, HLA class II alleles were not found to predispose to the disease in the Shanghai Chinese, suggesting that this haplotype is unlikely to be a universal susceptibility determinant. The absence of a disease association with the HLA-DR and -DQ genes in the Chinese population has a number of possible explanations. Our study suggests that other genetic and/or environmental components may be more important in determining susceptibility to MS in this race.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:12:11