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Titolo:
ATTENUATION OF IMMUNE-COMPLEX NEPHRITIS IN NZB W F1-MICE BY A PROSTACYCLIN ANALOG/
Autore:
UTSUNOMIYA Y; OGURA M; KAWAMURA T; MITARAI T; MARUYAMA N; SAKAI O;
Indirizzi:
JIKEI UNIV,SCH MED,DEPT INTERNAL MED 2,MINATO KU,3-19-18 NISHISHINBASHI TOKYO 105 JAPAN JIKEI UNIV,SCH MED,DEPT INTERNAL MED TOKYO 105 JAPAN SAITAMA MED SCH,SAITAMA MED CTR,DEPT INTERNAL MED SAITAMA JAPAN TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT MOLEC PATHOL TOKYO JAPAN
Titolo Testata:
Clinical and experimental immunology
fascicolo: 3, volume: 99, anno: 1995,
pagine: 454 - 460
SICI:
0009-9104(1995)99:3<454:AOININ>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULONEPHRITIS; PROSTAGLANDIN-E1; RAT; GLYCOPROTEIN; SUPPRESSION; INHIBITION; ANTIBODY; CULTURE; GROWTH; CELLS;
Keywords:
SYSTEMIC LUPUS ERYTHEMATOSUS; NEPHRITIS; NZB/W MICE; PROSTAGLANDIN PROSTACYCLIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
Y. Utsunomiya et al., "ATTENUATION OF IMMUNE-COMPLEX NEPHRITIS IN NZB W F1-MICE BY A PROSTACYCLIN ANALOG/", Clinical and experimental immunology, 99(3), 1995, pp. 454-460

Abstract

Although prostaglandins have been shown to inhibit the evolution of the nephritis in NZB/W mice, the mechanisms of this effect are unknown. To characterize such inhibition, we injected the prostacyclin (PGI(2)) analogue, beraprost, into NZB/W mice, using 0.5 mg, 1.0 mg or 5.0 mgberaprost/kg body weight of test animals three times in 1 week when the mice were 2 months old. Evaluation included measurement of urine albumin excretion, serological parameters and splenic T cell subset, as well as examination of renal histology by light and fluorescence microscopy. Mice given beraprost showed a marked decrease in urine albumin excretion and in glomerular hypercellularity compared with untreated controls. Maximal beneficial effects occurred when the dose was 5.0 mg/kg of beraprost. These effects correlated with a reduction of immune complex deposition in glomeruli. In addition, beraprost reduced serum levels of immunoglobulins and anti-double-stranded DNA antibodies, and decreased the number of helper (L3T4(+)) T cells in splenocytes. Theseresults indicate that beraprost attenuates the nephritis of NZB/W mice, and that the source of this effect is the reduced production of autoantibodies and deposition of immune complexes in glomeruli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:14:07