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Titolo:
SYNOVIAL-CELLS ARE POTENT ANTIGEN-PRESENTING CELLS FOR SUPERANTIGEN, STAPHYLOCOCCAL-ENTEROTOXIN-B (SEB)
Autore:
ORIGUCHI T; EGUCHI K; KAWABE Y; MIZOKAMI A; IDA H; NAGATAKI S;
Indirizzi:
NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED 1,1-7-1 SAKAMOTO NAGASAKI 852JAPAN NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED 1 NAGASAKI 852 JAPAN
Titolo Testata:
Clinical and experimental immunology
fascicolo: 3, volume: 99, anno: 1995,
pagine: 345 - 351
SICI:
0009-9104(1995)99:3<345:SAPACF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; INTERCELLULAR-ADHESION MOLECULE-1; RHEUMATOID-ARTHRITIS PATIENTS; MAMMARY-TUMOR VIRUS; CLASS-II MOLECULES; BLOOD MONONUCLEAR LEUKOCYTES; STREPTOCOCCAL-M-PROTEIN; T-CELLS; HLA-DR; MICROBIAL SUPERANTIGENS;
Keywords:
SUPERANTIGEN; STAPHYLOCOCCAL ENTEROTOXIN B; ANTIGEN-PRESENTING CELL; SYNOVIAL CELL; RHEUMATOID ARTHRITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
T. Origuchi et al., "SYNOVIAL-CELLS ARE POTENT ANTIGEN-PRESENTING CELLS FOR SUPERANTIGEN, STAPHYLOCOCCAL-ENTEROTOXIN-B (SEB)", Clinical and experimental immunology, 99(3), 1995, pp. 345-351

Abstract

There is ample evidence suggesting that superantigens may act as a triggering factor in the pathogenesis of rheumatoid arthritis (RA). We investigated whether superantigen could activate T cells in the presence of synovial cells. T cells were cultured with SEB in the presence ofinterferon-gamma (IFN-gamma)-treated synovial cells. T cell proliferation and activation were assessed by H-3-thymidine incorporation and IL-2 production. The expression of HLA class II antigens and adhesion molecules on synovial cells was detected by flow cytometer. In the presence of IFN-gamma-treated synovial cells, T cells proliferated vigorously and produced IL-2 in response to SEB. A low SEB-induced T cell response was noticed in the presence of untreated synovial cells. Allogeneic as well as autologous IFN-gamma-treated synovial cells markedly enhanced SEB-induced T cell proliferation. IFN-gamma-treated synovial cells had increased expression of HLA class II antigens and intercellular adhesion molecule-1 (ICAM-1) adhesion molecules. MoAbs towards theseantigens markedly inhibited the SEB-induced T cell response. These results indicate that activated synovial cells are potent antigen-presenting cells for SEB to T cells, and that superantigens may play a critical role in the pathogenesis of RA through activated synovial cells.

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Documento generato il 26/09/20 alle ore 14:50:46