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Titolo:
ABNORMAL PATTERNS OF EQUINE LEUKOCYTE DIFFERENTIATION ANTIGEN EXPRESSION IN SEVERE COMBINED IMMUNODEFICIENCY FOALS SUGGESTS THE PHENOTYPE OF NORMAL EQUINE NATURAL-KILLER-CELLS
Autore:
LUNN DP; MCCLURE JT; SCHOBERT CS; HOLMES MA;
Indirizzi:
UNIV WISCONSIN,SCH VET MED,DEPT MED SCI,2015 LINDEN DR MADISON WI 53706
Titolo Testata:
Immunology
fascicolo: 3, volume: 84, anno: 1995,
pagine: 495 - 499
SICI:
0019-2805(1995)84:3<495:APOELD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTES-T; HORSES; MICE; MATURATION; MUTATION; SUBSET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D.P. Lunn et al., "ABNORMAL PATTERNS OF EQUINE LEUKOCYTE DIFFERENTIATION ANTIGEN EXPRESSION IN SEVERE COMBINED IMMUNODEFICIENCY FOALS SUGGESTS THE PHENOTYPE OF NORMAL EQUINE NATURAL-KILLER-CELLS", Immunology, 84(3), 1995, pp. 495-499

Abstract

Severe combined immunodeficiency (SCID) is a fatal autosommal diseaseof Arabian horses that leads to failure of maturation of T- and B-lymphocyte populations, although natural killer (NK) cells are unaffected. Thymic and lymph node tissues from two foals suffering from SCID were examined in an immunohistological study using a panel of monoclonal antibodies recognising equine leucocyte differentiation antigens. In both foals, the majority of cells in lymphoid tissues had an EqCD3(-) EqCD4(-) EqCD8(+) phenotype, although rare EqCD3(+) cells were also detected. The EqCD3(-) EqCD4(-) EqCD8(+) cells may represent an abnormal lymphocyte differentiation product resulting from the SCID defect, or alternatively may be a normal equine NK cell population. We suggest that the evidence favours the latter proposal, and that equine NK cells in normal horses therefore may be identified by an EqCD3(-) EqCD8(+) phenotype. The implications for the nature of the equine SCID defect are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:36:00