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Titolo:
IMMUNOMODULATORY AND ANTIVIRAL ACTIVITIES OF 2',3'-DIDEOXY-BETA-L-CYTIDINE AND 2',3'-DIDEOXY-BETA-L-5-FLUOROCYTIDINE
Autore:
GAGNON L; NORDSTROM PA; DUCHAINE J; JUTRAS D; HAMEL M; BARBEAU D; HOOKER E; ASHMAN C; CAMMACK N; TSE A; MANSOUR T; YUEN L;
Indirizzi:
BIOCHEM THERAPEUT INC,DEPT VIROL IMMUNOL,275 ARMAND FRAPPIER BLVD QUEBEC CITY PQ H7V 4A7 CANADA BIOCHEM THERAPEUT INC,DEPT VIROL IMMUNOL QUEBEC CITY PQ H7V 4A7 CANADA BIOCHEM THERAPEUT INC,MED CHEM QUEBEC CITY PQ H7V 4A7 CANADA GLAXO RES & DEV LTD,DEPT VIROL GREENFORD UB6 0HE MIDDX ENGLAND
Titolo Testata:
Immunopharmacology and immunotoxicology
fascicolo: 1, volume: 17, anno: 1995,
pagine: 17 - 32
SICI:
0892-3973(1995)17:1<17:IAAAO2>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY SYNDROME AIDS; VIRUS TYPE-1; ZIDOVUDINE; REPLICATION; INVITRO; 2',3'-DIDEOXY-3'-THIACYTIDINE; DIDEOXYNUCLEOSIDES; INHIBITION; THERAPY; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L. Gagnon et al., "IMMUNOMODULATORY AND ANTIVIRAL ACTIVITIES OF 2',3'-DIDEOXY-BETA-L-CYTIDINE AND 2',3'-DIDEOXY-BETA-L-5-FLUOROCYTIDINE", Immunopharmacology and immunotoxicology, 17(1), 1995, pp. 17-32

Abstract

Two dideoxynucleosides, 2',3'-dideoxy-beta-L-cytidine and 2',3'-dideoxy-beta-L-5-fluorocytidine, containing unnatural L-configuration in their sugar moieties, were synthesized and assayed for antiviral activities. Both compounds were shown to possess potent anti-human immunodeficiency virus type 1 and antihepatitis B virus activities, while demonstrating no anti-herpes simplex viruses 1 and 2 activity, These two compounds exhibited in vitro cellular toxicities for several leukocytic cell lines and were shown to inhibit phytohemagglutinin-stimulated human peripheral blood mononuclear leukocyte proliferations. At inhibitoryconcentrations, both compounds caused accumulations of cells in the Sphase. While demonstrating no obvious morphological toxicity in vivo in mice at concentrations of 75 and 150 mg/kg, 2',3'-dideoxy-beta-L-5-fluorocytidine-treated animals were shown to have considerable increases in CD4/CD8 double positive T lymphocyte population in their blood circulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:24:36