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Titolo:
POSTPRANDIAL ALKALINE TIDE - DOES IT EXIST
Autore:
JOHNSON CD; MOLE DR; PESTRIDGE A;
Indirizzi:
UNIV SOUTHAMPTON,SOUTHAMPTON GEN HOSP,SURG UNIT,F LEVEL,CTR BLOCK,TREMONA RD SOUTHAMPTON SO9 4XY HANTS ENGLAND
Titolo Testata:
Digestion
fascicolo: 2, volume: 56, anno: 1995,
pagine: 100 - 106
SICI:
0012-2823(1995)56:2<100:PAT-DI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; RANITIDINE; VAGOTOMY;
Keywords:
GASTRIC SECRETION; ALKALINE TIDE; GASTRIC FUNCTION; H2 RECEPTOR ANTAGONISTS; VAGOTOMY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Johnson et al., "POSTPRANDIAL ALKALINE TIDE - DOES IT EXIST", Digestion, 56(2), 1995, pp. 100-106

Abstract

The concept of an alkaline tide which compensates for gastric acid secretion suggests the possibility of indirect measurement of gastric acid secretion. This study was designed to determine whether postprandial changes in renal and respiratory function could be used to assess gastric secretion in healthy adults. Volunteers ate one of three standard (low, medium or high protein) breakfasts on separate days. A fall inurine acid output was observed during 2 h after the high protein meal, but not after the medium or low protein meal. Fasting subjects showed a similar fall in urine acid output over a 2-hour period. Pretreatment with ranitidine 150 mg b.i.d. had no effect on basal or postprandial urine acid output. We conclude that changes in urine acid output arenot related to the gastric secretory response to food. In a separate study, treatment with omeprazole 20 mg daily had no effect on postprandial respiratory function (minute ventilation; mixed expired CO2; minute volume of CO2; respiratory exchange ratio; venous blood pH, pCO(2) or bicarbonate; and end tidal CO2). Thus we were unable to detect a respiratory alkaline tide after a standard breakfast. These findings suggest that any respiratory or urinary compensation for gastric acid secretion is too small to be of physiological or clinical significance.

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Documento generato il 12/07/20 alle ore 05:34:43