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Titolo:
SIGNIFICANCE OF 19-NORALDOSTERONE, A NEW MINERALOCORTICOID, IN CLINICAL AND EXPERIMENTAL-HYPERTENSION
Autore:
TAKEDA Y; MIYAMORI I; TAKEDA R;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2,13-1 TAKARA MACHI KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Steroids
fascicolo: 1, volume: 60, anno: 1995,
pagine: 137 - 142
SICI:
0039-128X(1995)60:1<137:SO1ANM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDOSTERONE-PRODUCING ADENOMA; SODIUM RESTRICTION; URINARY-EXCRETION; BLOOD-PRESSURE; 18,19-DIHYDROXYCORTICOSTERONE; 19-NOR-DEOXYCORTICOSTERONE; 18-HYDROXY-19-NORCORTICOSTERONE; 19-NOR-ALDOSTERONE; RATS; 18-DEOXY-19-NORALDOSTERONE;
Keywords:
19-NORALDOSTERONE; 19-NOR-DOC; 18,19-(OH)(2)-B; 18-OH-B; 18-OH-F; ALDOSTERONE; HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "SIGNIFICANCE OF 19-NORALDOSTERONE, A NEW MINERALOCORTICOID, IN CLINICAL AND EXPERIMENTAL-HYPERTENSION", Steroids, 60(1), 1995, pp. 137-142

Abstract

19-Noraldosterone, which was recently shown to be synthesized and produced in the human adrenal gland, possesses potent mineralocorticoid and hypertensinogenic activities. 18,19-Dihydroxycorticosterone (18,19(OH)(2)-B) and 18-hydroxy-19-norcorticosterone (18-OH-19-nor-B), a possible precursor of 19-noraldosterone, have been identified in human urine. These mineralocorticoid hormones are regulated by the renin-angiotensin system and synthesized in adrenal glomerulosa cells. Urinary 19-noraldosterone correlated with urinary 18,19(OH)(2)-B, 18-OH-19-nor-B,18-hydroxycorticosterone (18-OH-B), and aldosterone. Urinary excretion of 19-noraldosterone, 18,19-(OH)(2)-B, and 18-OH-19-nor-B were increased in patients with aldosterone-producing adenoma (APA) and in thosewith idiopathic hyperaldosteronism (IHA), but the two did not differ significantly. Urinary 18-OH-B and 18-hydroxycortisol (18-OH-F) were significantly higher in APA compared with IHA. Though urinary 18-OH-F and 18-OH-B concentrations were useful markers, urinary 19-noraldosterone, 18,19(OH)(2)-B, and 18-OH-19-nor-B could not be used to distinguish the two subsets of primary aldosteronism. Urinary 19-noraldosterone did not differ in hypertensive and normotensive patients. However, urinary 19-noraldosterone was increased in some hypertensive patients. Inspontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP), urinary 19-noraldosterone was increased at the prehypertensive stage compared with Wistar-Kyoto (WKY) rats. Urinary 19-noraldosterone was decreased in 9-week-old SHR and SHRSP compared with WKY rats. However urinary 19-noraldosterone was higher in SHRSP than in SHR. These elevatedlevels of 19-noraldosterone may contribute to hypertension in some individuals and in experimental hypertensive rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:24:54