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Titolo:
ALDOSTERONE BIOSYNTHESIS AND ACTION IN VASCULAR CELLS
Autore:
TAKEDA R; HATAKEYAMA H; TAKEDA Y; IKI K; MIYAMORI I; SHENG WP; YAMAMOTO H; BLAIR IA;
Indirizzi:
KKR,HOKURIKU HOSP,DEPT INTERNAL MED,IZUMIGAOKA 2-13-43 KANAZAWA 921 ISHIKAWA JAPAN KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2 KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT BIOCHEM KANAZAWA ISHIKAWA 920 JAPAN VANDERBILT UNIV,SCH MED,DIV CLIN PHARMACOL NASHVILLE TN 37212
Titolo Testata:
Steroids
fascicolo: 1, volume: 60, anno: 1995,
pagine: 120 - 124
SICI:
0039-128X(1995)60:1<120:ABAAIV>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN; EXPRESSION; RECEPTOR; CLONING; BINDING; WALL; RATS;
Keywords:
VASCULAR ALDOSTERONE; P450(ALDO) GENE; MINERALOCORTICOID RECEPTOR; EX VIVO MESENTERIC ARTERY PERFUSION; ACE-INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
R. Takeda et al., "ALDOSTERONE BIOSYNTHESIS AND ACTION IN VASCULAR CELLS", Steroids, 60(1), 1995, pp. 120-124

Abstract

In view of the hypothetical possibility that the vascular renin-angiotensin system (RAS) might include aldosterone biosynthesis and action in the vasculature, we have undertaken a study to identify aldosteronereleased into the perfusion circuit from the rat mesenteric artery, and to investigate the effects of an angiotensin converting enzyme inhibition (ACEI) on aldosterone production from the vasculature. After 30min equilibration, 240 mt of perfusate was collected and subjected toreverse-phase HPLC and subsequent mass spectrometry. Mass spectra corresponding to authentic corticosterone and aldosterone were obtained from the samples of mesenteric artery perfusate. Production of aldosterone in the mesenteric artery was not changed by adrenalectomy, although it was reduced in the arterial perfusate from rats pretreated with ACEI. By RT-PCR the expression of CYP 11B2 and mineralocorticoid receptor genes were demonstrated in both vascular endothelial and smooth muscle cells. These studies constitute indirect evidence supporting our hypothesis that locally produced aldosterone in the vascular tissue acts on vascular tone and remodeling via a paracrine or autocrine manner.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:50:25