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Titolo:
DEVELOPMENT OF AN ANIMAL-MODEL FOR NEUROLEPTIC MALIGNANT SYNDROME - HEAT-EXPOSED RABBITS WITH HALOPERIDOL AND ATROPINE ADMINISTRATION EXHIBIT INCREASED MUSCLE-ACTIVITY, HYPERTHERMIA, AND HIGH SERUM CREATINE-PHOSPHOKINASE LEVEL
Autore:
TANII H; TANIGUCHI N; NIIGAWA H; HOSONO T; IKURA Y; SAKAMOTO S; KUDO T; NISHIMURA T; TAKEDA M;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT NEUROPSYCHIAT,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT NEUROPSYCHIAT & PHYSIOL SUITA OSAKA 565 JAPAN KOSHIEN UNIV,COLL NUTR TAKARAZUKA HYOGO 665 JAPAN
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 743, anno: 1996,
pagine: 263 - 270
SICI:
0006-8993(1996)743:1-2<263:DOAAFN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MUSCULAR RIGIDITY; LOCUS-COERULEUS; RATS; INVOLVEMENT;
Keywords:
HALOPERIDOL; ATROPINE; DANTROLENE SODIUM; FORCED HYPERTHERMIA; CREATINE PHOSPHOKINASE; MUSCLE RIGIDITY; SET-POINT; NEUROLEPTIC MALIGNANT SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
H. Tanii et al., "DEVELOPMENT OF AN ANIMAL-MODEL FOR NEUROLEPTIC MALIGNANT SYNDROME - HEAT-EXPOSED RABBITS WITH HALOPERIDOL AND ATROPINE ADMINISTRATION EXHIBIT INCREASED MUSCLE-ACTIVITY, HYPERTHERMIA, AND HIGH SERUM CREATINE-PHOSPHOKINASE LEVEL", Brain research, 743(1-2), 1996, pp. 263-270

Abstract

The neuroleptic malignant syndrome (NMS) is a life-threatening complication of neuroleptic treatment. To elucidate the pathogenesis of NMS,an animal model has been developed. Experimental rabbits treated withhaloperidol (1 mg/kg) by intramuscular injection, were studied for the diagnostic symptoms of increased muscle rigidity, elevated body temperature, and high serum creatine phosphokinase (CPK) level. Administration of haloperidol (1 mg/kg) and atropine (0.4 mg/kg), and exposure to high ambient temperature (35 degrees C) induced a significant increase in electromyographic activity with muscle rigidity similar to that observed in patients with NMS. Such rabbits also showed elevated body temperature and serum CPK value. In addition to the similarity of the signs and symptoms, all parameters measured (muscle rigidity, body temperature, and serum CPK level) were normalized by dantrolene treatment. The effectiveness of dantrolene in the experimental animal partiallyconfirms the validity of this animal model for NMS. This experimentalanimal model for NMS may be useful to elucidate the pathogenesis of NMS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:55:17