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Titolo:
ANTIDIURETIC ACTION OF TACHYKININ NK-3 RECEPTOR IN THE RAT PARAVENTRICULAR NUCLEUS
Autore:
EGUCHI T; TAKANO Y; HATAE T; SAITO R; NAKAYAMA Y; SHIGEYOSHI Y; OKAMURA H; KRAUSE JE; KAMIYA H;
Indirizzi:
FUKUOKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL FUKUOKA 81480 JAPAN FUKUOKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL FUKUOKA 81480 JAPAN KOBE UNIV,SCH MED,DEPT ANAT & NEUROBIOL KOBE 650 JAPAN WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL ST LOUIS MO 63110
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 743, anno: 1996,
pagine: 49 - 55
SICI:
0006-8993(1996)743:1-2<49:AAOTNR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-PREFERRING RATS; SELECTIVE AGONISTS; VASOPRESSIN; RELEASE; ANTAGONIST; SENKTIDE; BRAIN;
Keywords:
TACHYKININ; NK-3 RECEPTOR; ANTIDIURETIC ACTION; PARAVENTRICULAR NUCLEUS; VASOPRESSIN V2 RECEPTOR; SENKTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T. Eguchi et al., "ANTIDIURETIC ACTION OF TACHYKININ NK-3 RECEPTOR IN THE RAT PARAVENTRICULAR NUCLEUS", Brain research, 743(1-2), 1996, pp. 49-55

Abstract

Studies were performed on the central antidiuretic actions via the tachykinin NK-3 receptor in the rat hypothalamic paraventricular nucleus(PVN). Microinjections of the selective tachykinin NK-3 receptor agonist senktide (2-200 pmol) into the PVN resulted in prolonged inhibition of urine output in water-loaded rats, its effect being dose-dependent. The antidiuretic action of senktide was blocked by pretreatment with the vasopressin V2 receptor antagonist OPC-31260 (1 mg/kg, i.v.), but not by microinjection of the angiotensin II AT-1 receptor antagonistlosartan (1 nmol) into the PVN. NK-3 receptor mRNA was strongly detected in the magnocellular part of the PVN and the supraoptic nucleus (SON) of the hypothalamus as detected by in situ hybridization histochemistry. Moreover, [H-3]senktide binding sites were also detected in thePVN and the SON by receptor autoradiography. These findings suggest that NK-3 receptors in the PVN may be involved in water regulation by stimulation of vasopressin secretion from the posterior pituitary gland, and that vasopressin caused water reabsorbtion via the kidney V2 receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:00:00