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Titolo:
VITAMIN-D AND PUBERTAL MATURATION - INTER EST AND TOLERANCE OF VITAMIN-D SUPPLEMENTATION DURING THE WINTER
Autore:
ZEGHOUD F; DELAVEYNE R; REHEL P; CHALAS J; GARABEDIAN M; ODIEVRE M;
Indirizzi:
UNIV PARIS 05,HOP ST VINCENT DE PAUL,CNRS,URA 583,82 AVE DENFERT ROCHEREAU F-75014 PARIS FRANCE HOP ANTOINE BECLERE,SERV PEDIAT F-92140 CLAMART FRANCE HOP ANTOINE BECLERE,SERV BIOCHIM F-92140 CLAMART FRANCE
Titolo Testata:
Archives de pediatrie
fascicolo: 3, volume: 2, anno: 1995,
pagine: 221 - 226
SICI:
0929-693X(1995)2:3<221:VAPM-I>2.0.ZU;2-F
Fonte:
ISI
Lingua:
FRE
Soggetto:
D METABOLITES; 1,25-DIHYDROXYVITAMIN-D LEVELS; SERUM 1,25-DIHYDROXYVITAMIN-D; GROWTH;
Keywords:
VITAMIN-D; VITAMIN-D DEFICIENCY; PUBERTY; ADOLESCENT MEDICINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
F. Zeghoud et al., "VITAMIN-D AND PUBERTAL MATURATION - INTER EST AND TOLERANCE OF VITAMIN-D SUPPLEMENTATION DURING THE WINTER", Archives de pediatrie, 2(3), 1995, pp. 221-226

Abstract

Background. - In France, several cases of vitamin D-deficiency rickets among adolescents have been reported, but no prophylaxis measure hasbeen systematically recommended at this age. The aim of this study was to measure 25-hydroxyvitamin D (25-(OH)D) levels and to search for biological signs of vitamin D deficiency during adolescence. Moreover, the effects of a unique oral dose of 100 000 IU of vitamin D3, given during the winter, were analysed. Population and methods. - Circulatinglevels of 25-(OH)D, 1,25-dihydroxyvitamin D, intact parathyroid hormone (iPTH), alkaline phosphatase activities, calcium and phosphate weremeasured in 53 adolescents aged 10-17 years (81% of metropolitan origin), seen during the winter. The effect of a single oral dose of 100 000 IU of vitamin D3 or of placebo was studied in 15 of these subjects. Results. - 24,5% of the adolescents had low 25-(OH)D concentrations (< 6 ng/ml), this frequency being even more elevated (38%) at the end of pubertal maturation (stages 4 and 5). An increase in iPTH concentrations was found in subjects with lowest 25-(OH)D levels (< 3 ng/ml). Anoral dose of 100 000 IU of vitamin D3 resulted in a significant increase in the 25-(OH)D levels; yet, these levels remained within the normal range during the 1-2 month follow-up of the nine treated subjects. This dosage made it possible to correct the low calcium concentrations(2.20-2.24 mmol/l) found before treatment in three adolescents. Conclusions. - The high frequency of low vitamin D status observed during puberty and its normalization after a 100 000 IU vitamin D3 supplementation show the interest and safety of this intermittent 100 000 IU vitamin D3 supplementation to adolescents during the winter season.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:11:05