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Titolo:
SEX, AGE, AND DISEASE AFFECT ECHOCARDIOGRAPHIC LEFT-VENTRICULAR MASS AND SYSTOLIC FUNCTION IN THE FREE-LIVING ELDERLY - THE CARDIOVASCULAR HEALTH STUDY
Autore:
GARDIN JM; SISCOVICK D; ANTONCULVER H; LYNCH JC; SMITH VE; KLOPFENSTEIN HS; BOMMER WJ; FRIED L; OLEARY D; MANOLIO TA;
Indirizzi:
CHS COORDINATING CTR,CENTURY SQ,1501 4TH AVE,SUITE 2025 SEATTLE WA 98101 UNIV CALIF IRVINE,DEPT MED,DIV CARDIOL IRVINE CA 00000 UNIV CALIF IRVINE,DEPT MED,DIV EPIDEMIOL IRVINE CA 00000 UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT MED SEATTLE WA 00000 UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT EPIDEMIOL SEATTLE WA 00000 UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT BIOSTAT SEATTLE WA 00000 ALBANY MED COLL,DIV CARDIOL ALBANY NY 00000 BOWMAN GRAY SCH MED,DEPT MED,DIV CARDIOL WINSTON SALEM NC 00000 UNIV CALIF DAVIS,DEPT MED,DIV CARDIOL SACRAMENTO CA 00000 JOHNS HOPKINS MED INST,DEPT MED BALTIMORE MD 00000 JOHNS HOPKINS MED INST,DEPT EPIDEMIOL BALTIMORE MD 00000 GEISINGER MED CTR,DEPT RADIOL DANVILLE PA 00000 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 00000
Titolo Testata:
Circulation
fascicolo: 6, volume: 91, anno: 1995,
pagine: 1739 - 1748
SICI:
0009-7322(1995)91:6<1739:SAADAE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-DISEASE; POPULATION; ADULTS; IMPACT;
Keywords:
ECHOCARDIOGRAPHY; MULTICENTER STUDY; AGING; CARDIOVASCULAR DISEASES; VENTRICLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Gardin et al., "SEX, AGE, AND DISEASE AFFECT ECHOCARDIOGRAPHIC LEFT-VENTRICULAR MASS AND SYSTOLIC FUNCTION IN THE FREE-LIVING ELDERLY - THE CARDIOVASCULAR HEALTH STUDY", Circulation, 91(6), 1995, pp. 1739-1748

Abstract

Background Left ventricular (LV) hypertrophy, as measured by M-mode echocardiography, is an independent predictor of mortality and/or morbidity from coronary heart disease (CHD). LV global and segmental systolic dysfunction also have been associated with myocardial ischemia and cardiovascular morbidity and mortality. Echocardiographic data, especially two-dimensional, have not been available previously from multicenter-based studies of the elderly. This report describes the distribution and relation at baseline of echocardiographic LV mass and global and segmental LV wall motion to age, sex, and clinical disease category in the Cardiovascular Health Study (CHS), a cohort of 5201 men and women (4850 white) 65 years of age and older. Methods and Results M-mode LV mass adjusted for body weight increased modestly with age (P<.0001), increasing less than one gram per year increase in age for both men and women. After adjustment for weight, LV mass was significantly greater in men than in women and in participants with clinical CHD compared with participants with neither clinical heart disease nor hypertension (both P<.001). Across all CHS age subgroups, the difference in weight-adjusted LV mass by sex was greater in magnitude than the difference related to clinical CHD. M-mode measurements of LV mass could not bemade in 34% of CHS participants, and this was highly related to age (29% in the 65 to 69 year versus 50% in the 85+ year age group, P<.001)and other risk factors. In participants with clinical CHD and with neither clinical heart disease nor hypertension, LV ejection fraction and segmental wall motion abnormalities were more prevalent in men than women (all P<.001). Of interest, 0.5% of men and 0.4% of women with neither clinical heart disease nor hypertension had LV segmental wall motion abnormalities, suggesting silent disease, compared with 26% of men and 10% of women in the clinical CHD group (P<.0001). Multivariate analyses revealed male sex and presence of clinical CHD (both P<.001) to be independent predictors of LV akinesis or dyskinesis. Conclusions Significant baseline relations were detected between differences in sex, prevalent disease status, and echocardiographic measurements of LV mass and systolic function in the CHS cohort. Age was weakly associated with LV mass measurements and LV ejection fraction abnormalities. These relations should be considered in evaluating the preclinical and clinical effects of CHD risk factors in the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:42:00