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Titolo:
THE DORSAL NORADRENERGIC BUNDLE MODULATES DNA REMODELING IN THE RAT-BRAIN UPON EXPOSURE TO A SPATIAL NOVELTY
Autore:
SADILE AG; CERBONE A; LAMBERTIDMELLO C; AMOROSO S; ANNUNZIATO L; MENNA T; BUONO C; RAFTI F; GIUDITTA A;
Indirizzi:
UNIV NAPLES 2,DEPT HUMAN PHYSIOL F BOITAZZI,NEUROPHYSIOL BEHAV & NEURAL NETWORKS LAB I-80138 NAPLES ITALY UNIV NAPLES 2,DEPT GEN & ENVIRONM PHYSIOL,PHARMACOL SECT NAPLES ITALY UNIV NAPLES 2,DEPT NEUROSCI,PHARMACOL SECT NAPLES ITALY CNR,INT INST GENET & BIOPHYS I-80125 NAPLES ITALY
Titolo Testata:
Brain research bulletin
fascicolo: 1, volume: 37, anno: 1995,
pagine: 9 - 16
SICI:
0361-9230(1995)37:1<9:TDNBMD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL DENTATE GYRUS; CENTRAL-NERVOUS-SYSTEM; LONG-LASTING POTENTIATION; LOCUS COERULEUS; REVERSE TRANSCRIPTION; TERM POTENTIATION; NOREPINEPHRINE; NEURONS; ADULT; CELLS;
Keywords:
UNSCHEDULED BRAIN DNA SYNTHESIS; H-3 THYMIDINE INCORPORATION; BEHAVIORAL HABITUATION; NONASSOCIATIVE LEARNING; SPATIAL NOVELTY; 6-HYDROXYDOPAMINE LESION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
A.G. Sadile et al., "THE DORSAL NORADRENERGIC BUNDLE MODULATES DNA REMODELING IN THE RAT-BRAIN UPON EXPOSURE TO A SPATIAL NOVELTY", Brain research bulletin, 37(1), 1995, pp. 9-16

Abstract

A series of experiments were designed to study the role of the dorsalnoradrenergic bundle (DNB) in the modulation of genomic remodeling inthe mammalian brain. A series of experiments were designed to study the role of the dorsal noradrenergic system in relation to nonassociative tasks. Adult male Sprague-Dawley rats were either bilaterally lesioned in the DNB by intrabundle microinjection of B-hydroxydopamine or were sham lesioned. All rats were given 50 mu Ci [H-3-methyl]-thymidineand were sacrificed 0.5 h later. After the injection of the tracer, rats were either left undisturbed in the home cage or were exposed to aLat-maze for 15 min after 15 min had passed from the time of injection, During the exposure to the maze, corner crossings and rearings weremonitored. The rate of DNA synthesis was determined in several brain regions by measuring the amount of tracer incorporated into the DNA over a 0.5-h duration pulse. Under baseline conditions DNB-lesioned ratsshowed an increase in DNA synthesis in the hippocampus, hypothalamus,and rest of the brain. On the other hand, following exposure to the Lat-maze, sham-lesioned rats only showed an increase in DNA synthesis in the hippocampus, as compared to baseline conditions. Conversely, DNB-lesioned rats did not show an increase in hippocampal DNA synthesis as in the sham-lesioned rats. In contrast, DNA synthesis was increased in the neocortex and rest of the brain. In conclusion, the data support a role for noradrenergic systems in modulating brain DNA synthesis, probably of the unscheduled type, during information processing and storage.

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Documento generato il 30/03/20 alle ore 13:15:38