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Titolo:
ORAL CAPTOPRIL VERSUS PLACEBO AMONG 13634 PATIENTS WITH SUSPECTED ACUTE MYOCARDIAL-INFARCTION - INTERIM-REPORT FROM THE CHINESE CARDIAC STUDY (CCS-1)
Autore:
LIU LS; WANG W; PAN XW; CHEN ZM; COLLINS R; PETO R; TAO SC; LIU LS; CHEN HZ; GONG LS; CHEN SX; CUI JJ; FANG C; WU XG; GUO XR; BAI MY; FANG WQ; HAO JS; WANG W; WU AL; LI HS; HE XY; LI X; MA LY; WANG LH; HONG ZG; WU SY; DIN WH; WANG JY; SHUN NL; LI YC; YIN GX; ZHUN DC; ZHOU BL; LI JZ; LI JY; HUANG JY; ZHAO YY; SHI XY; WANG GH; CHEN ZY; GE H; KUN XT; HU ZX; HUN HX; LI X; TUN WR; CHAO ZC; LI DZ; FU RN; WANG JY; WANG ML; KANG SP; LI H; LI Y; GAO GD; GUO WQ; HONG ZG; ZHANG ZG; GAO BW; LUE W; JIN YZ; TU XH; RU H; WANG SL; GAO J; ZHANG RY; WEN ZY; JIANG YQ; ZHANG CX; XIE HF; ZENG DY; GUO BX; TUN M; YE XY; LIU YH; LI HF; SHUN JL; XU GY; XU BY; ZHANG XL; WANG DM; ZHAO XL; SHUN DL; QU NL; WANG FQ; ZHOU Z; LIU JY; ZHOU SM; HAO LQ; SHUN NQ; FENG Y; LI XH; SHUN BF; ZHEN JS; WANG QX; ZHANG Y; PIAO YS; WANG XW; ZHUANG YM; LI FJ; SHI HZ; ZHANG SX; WANG WM; WU LL; LI WX; WANG YF; SHUN S; HUNG TG; SHEN ZF; SHI JL; CHEN DS; NI SZ; LIU YS; TANG HY; JIANG YC; ZHOU TC; GAO CR; CHEN Y; CHEN Z; LIN K; LIU YF; BAI JH; LI ZY; JIANG TM; MA G; MEN HH; PAN W; CHEN JY; ZHANG WQ; FENG H; ZHU DQ; LI XF; WANG SZ; ZHANG ZB; ZHANG F; REN GZ; SHUN QB; ZHANG QY; GEN HY; YANG QM; ZHONG PL; JIN ZG; CUI JY; XU HB; GUO YQ; WANG FZ; WANG TM; WANG ZH; CHEN YS; CHEN QQ; XIANG RX; FAN XT; LUO SJ; DENG SZ; MU RQ; DU M; SHUN YQ; LI LM; YOU NZ; ZHANG GZ; XU GF; HUANG XZ; DU QS; HUA ZS; YUAN BM; WEI W; QIAO DR; WANG XZ; ZHAN GE; YU FC; NING PY; MA JJ; GU LH; SHU QL; LI ZG; WU WC; WANG HM; WANG WB; SHI RZ; XIA HQ; ZHANG XS; ZHANG XZ; ZHAO XL; ZHANG S; LIU ZH; ZHANG GQ; LI GL; LIU ZM; WANG BW; ZHOU FJ; LIU TK; GUO X; GUO XW; LIU WD; ZHANG DX; WANG C; LU JX; SHU HC; WU LJ; MEN TY; ZHANG SH; LUO JZ; ZHEN Y; DAI GZ; FENG KY; LU YX; ZHEN YL; WANG RY; CAO MY; XU JL; HU XY; MU G; ZHU ZH; ZHANG QL; CHEN JQ; CHEN ZF; LI ZX; XIA JX; DIA ZD; YAN XL; LIU RY; WEI JH; HUANG ZW; ZHAO G; KUN XY; SHEN YX; XIAO X; ZHANG CX; MIAO YH; ZHANG ZY; YAN YX; MA HB; WANG SQ; OUYANG CQ; ZHAO WX; HE P; WANG JF; LI XB; LI GQ; HUANG XH; CHUI TX; QIAO CL; HUANG YL; LIU FQ; SHUN YQ; SHUN JS; LIU CR; CHEN GJ; YANG XZ; YU CQ; ZHAO CY; ZHANG JT; LIU Z; LI YQ; LIU ZM; ZHANG PY; WANG ZX; REN LJ; LIANG ZZ; ZHAO ZL; LI BR; HUANG RY; WANG ZJ; DU SL; XU DY; WANG ZY; WANG YG; WANG XP; WANG DP; LI QY; ZHOU M; ZHOU JC; MA FZ; LI RS; MA ZQ; ZHOU JX; LI PX; HUANG P; WU SL; FENG JZ; HOU JX; XU KL; QU ZY; LI ZJ; ZHANG YJ; LUO WH; YUANG EY; HUANG YH; XU KJ; FANG WH; YANG DY; WANG WM; ZUO JQ; SHI P; ZHAO LY; ZHANG AM; YAN KG; DONG GX; HUANG J; ZHANG SQ; DU FC; LU DC; SHEN LL; GU JG; CA MF; SHI GF; PAN XW; QI WH; TONG BG; DAI RH; ZHANG GY; CHEN SC; CUI SZ; CHEN WC; HE ZY; HUANG DJ; PAN PW; WANG MH; XU Q; HU LX; HU WY; ZHANG TH; CHEN SL; SHA Y; LIN YH; LIU XF; LU JF; FANG Q; NA L; SHU DY; WU HP; CHEN ZW; ZHANG MX; YAO Z; CHE GL; WU LY; FANG Y; ZHEN XB; GUO YC; ZHOU Y; HU JS; YAO LY; WU ZY; XIA SY; ZHANG LY; CHEN XK; XIA ZN; HUANG DJ; CHEN XP; TANG FR; HE GX; LIU S; CHEN J; KUANG YZ; XIN N; HE BX; FENG YY; CHEN ZH; TAN JZ; ZHANG FG; LU YH; HU SH; CHAO WF; REN GJ; WANG SL; ZHEN SS; SHUN M; WANG ZL; OUYANG GY; LIN ZD; CHEN H; LU JQ; QIN WJ;
Indirizzi:
CHINESE ACAD MED SCI,INST CARDIOVASC BEIJING 100037 PEOPLES R CHINA CHINESE ACAD MED SCI,FU WAI HOSP BEIJING 100037 PEOPLES R CHINA
Titolo Testata:
Lancet
fascicolo: 8951, volume: 345, anno: 1995,
pagine: 686 - 687
SICI:
0140-6736(1995)345:8951<686:OCVPA1>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
3
Recensione:
Indirizzi per estratti:
Citazione:
L.S. Liu et al., "ORAL CAPTOPRIL VERSUS PLACEBO AMONG 13634 PATIENTS WITH SUSPECTED ACUTE MYOCARDIAL-INFARCTION - INTERIM-REPORT FROM THE CHINESE CARDIAC STUDY (CCS-1)", Lancet, 345(8951), 1995, pp. 686-687

Abstract

13 634 patients entering 650 Chinese hospitals up to 36 h after the onset of suspected acute myocardial infarction (MI) were randomised between one month of oral captopril (6.25 mg initial dose, 12.5 mg 2 h later, and then 12.5 mg three times daily) or matching placebo. Captopril was associated with a non-significant reduction in 4-week mortality (617 [9.05%] captopril-allocated vs 654 [9.59%] placebo-allocated deaths; 2p=0.3). There was a significant excess of hypotension, mostly early after the start of treatment, but no evidence of any adverse effecton early mortality (even among patients who were hypotensive at entry). Taken together with the other trials of converting enzyme inhibitors started early in acute MI, these results indicate that such therapy is generally safe and typically prevents about 5 deaths per 1000 patients treated for the first month.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 07:01:10