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Titolo:
RADIOLABELED CHIMERIC ANTI-CEA MONOCLONAL-ANTIBODY COMPARED WITH THE ORIGINAL MOUSE MONOCLONAL-ANTIBODY FOR SURGICALLY TREATED COLORECTAL-CARCINOMA
Autore:
BUCHEGGER F; MACH JP; PELEGRIN A; GILLET M; VOGEL CA; BUCLIN T; RYSER JE; DELALOYE B; DELALOYE AB;
Indirizzi:
CHU VAUDOIS,DEPT SURG,DIV NUCL MED CH-1011 LAUSANNE SWITZERLAND CHU VAUDOIS,DEPT CLIN PHARMACOL CH-1011 LAUSANNE SWITZERLAND UNIV LAUSANNE,INST BIOCHEM LAUSANNE SWITZERLAND HOP CANTONAL UNIV GENEVA,DEPT NUCL MED GENEVA SWITZERLAND
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 3, volume: 36, anno: 1995,
pagine: 420 - 429
SICI:
0161-5505(1995)36:3<420:RCAMCW>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-COLON-CARCINOMA; B-CELL LYMPHOMA; CARCINOEMBRYONIC ANTIGEN; NUDE-MICE; F(AB')2 FRAGMENTS; IMMUNE-RESPONSE; RADIOIMMUNOTHERAPY; THERAPY; CANCER; IMMUNOSCINTIGRAPHY;
Keywords:
CHIMERIC MONOCLONAL ANTIBODY; CARCINOEMBRYONIC ANTIGEN; TUMOR UPTAKE; COLORECTAL CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
F. Buchegger et al., "RADIOLABELED CHIMERIC ANTI-CEA MONOCLONAL-ANTIBODY COMPARED WITH THE ORIGINAL MOUSE MONOCLONAL-ANTIBODY FOR SURGICALLY TREATED COLORECTAL-CARCINOMA", The Journal of nuclear medicine, 36(3), 1995, pp. 420-429

Abstract

Biodistribution and tumor uptake of a chimeric human-mouse monoclonalantibody (MAb) and the original mouse MAb have been comparatively studied. Methods: Eighteen patients with suspected colorectal cancer scheduled for surgery underwent immunoscintigraphy with I-123-labeled chimeric anti-CEA MAb. iodine-125 and I-131 trace-labeled chimeric and original mouse MAb were simultaneously injected for biodistribution studies. Results: Similar serum kinetics and a low immunogenicity were observed for both antibodies. Mean binding capacity to CEA measured in PBSafter radiolabeling was identical for both MAbs and it was slightly decreased when measured in serum 1-4 hr after injection. Radiochromatograms of patients sera showed immune complex formation related to the amount of circulating CEA. Postoperative ex vivo radioactivity countingin tissue samples revealed similar antibody distributions with notably similar antibody uptakes in tumors. High tumor uptakes (between 0.02to 0.06% injected dose per g) were observed in 3 of 13 patients operated for primary or metastatic colorectal cancer. Conclusion: In this dual-label technique, the radioiodinated anti-CEA IgG(4) chimeric MAb and the original mouse IgG(1) MAb were shown to have very similar behavior in colorectal cancer patients.

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Documento generato il 25/01/21 alle ore 16:28:12