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Titolo:
EFFECTS OF HYPOCHLORHYDRIA AND HYPERGASTRINEMIA ON STRUCTURE AND FUNCTION OF GASTROINTESTINAL CELLS - A REVIEW AND ANALYSIS
Autore:
FRESTON JW; BORCH K; BRAND SJ; CARLSSON E; CREUTZFELDT W; HAKANSON R; OLBE L; SOLCIA E; WALSH JH; WOLFE MM;
Indirizzi:
UNIV CONNECTICUT,CTR HLTH,DEPT MED FARMINGTON CT 06030 LINKOPING UNIV HOSP,DEPT SURG S-58185 LINKOPING SWEDEN MASSACHUSETTS GEN HOSP,GASTROINTESTINAL UNIT BOSTON MA 02114 ASTRA HASSLE AB MOLNDAL SWEDEN UNIV GOTTINGEN,DIV GASTROENTEROL & ENDOCRINOL W-3400 GOTTINGEN GERMANY LUND UNIV,DEPT PHARMACOL LUND SWEDEN SAHLGRENS UNIV HOSP,DEPT SURG 2 GOTHENBURG SWEDEN UNIV PAVIA,DEPT HUMAN PATHOL I-27100 PAVIA ITALY UNIV CALIF LOS ANGELES,VET ADM WADSWORTH MED CTR,SCH MED LOS ANGELES CA 90073 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DIV GASTROENTEROL BOSTON MA 02115
Titolo Testata:
Digestive diseases and sciences
fascicolo: 2, volume: 40, anno: 1995, supplemento:, S
pagine: 50 - 62
SICI:
0163-2116(1995)40:2<50:EOHAHO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; GROWTH-FACTOR-ALPHA; PERFUSED RAT STOMACH; ZOLLINGER-ELLISON SYNDROME; DUODENAL-ULCER PATIENTS; CANINE PARIETAL-CELLS; MULTIPLE ENDOCRINE NEOPLASIA; 24-HOUR INTRAGASTRIC ACIDITY; LONG-TERM TREATMENT; PLASMA-GASTRIN;
Keywords:
OMEPRAZOLE; HYPOCHLORHYDRIA; HYPERGASTRINEMIA; ENTEROCHROMAFFIN-LIKE CELL CARCINOIDS; PEPTIC ULCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
152
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Freston et al., "EFFECTS OF HYPOCHLORHYDRIA AND HYPERGASTRINEMIA ON STRUCTURE AND FUNCTION OF GASTROINTESTINAL CELLS - A REVIEW AND ANALYSIS", Digestive diseases and sciences, 40(2), 1995, pp. 50-62

Abstract

Since hypochlorhydria can induce hypergastrinemia, and gastrin has a trophic effect on some gastrointestinal cells, states that cause elevated plasma gastrin levels are of interest in terms of effects on cell growth and function. This article reviews the relationship between gastric mucosal cells during periods of acid stimulation and inhibition and analyses the effects of hypochlorhydria and hypergastrinemia on gastric and colonic cells and tumors. Hypochlorhydria releases the inhibitory effect of antral gastrin cells, inducing them to release gastrin in the presence of peptides or amino acids in the gastric lumen or in response to antral distension. Gastrin stimulates the oxyntic mucosa, which may lead to hyperplasia of enterochromaffin-like cells, resulting in enterochromaffin-like carcinoid tumors in aged rats and, rarely, in patients with chronic atrophic gastritis or gastrinomas. In addition to hypergastrinemia, other factors appear to be required for the progression of enterochromaffin-like hyperplasia to carcinoids; genetic factors may be involved. Gastrin elevations due to anti-secretory drug therapy are indirectly proportional to the degree of acid inhibition and are reversible upon cessation of therapy. The gastrin levels duringomeprazole therapy are similar to those caused by gastric vagotomy. Available evidence does not support a relationship between hypergastrinemia and the occurrence or growth of gastric carcinoma or colonic tumors.

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Documento generato il 24/11/20 alle ore 10:30:58