Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE EFFECT OF THE FAT-CONTENT OF FOOD ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF SDZ FOX-988, AN ANTIDIABETIC AGENT, IN THE DOG
Autore:
LAU DTW; KALAFSKY G; AUN RL; TSE FLS;
Indirizzi:
SANDOZ PHARMACEUT CORP,SANDOZ RES INST,DRUG SAFETY,DEPT DRUG METAB & PHARMACOKINET E HANOVER NJ 07936 SANDOZ PHARMACEUT CORP,SANDOZ RES INST,DRUG SAFETY,DEPT DRUG METAB & PHARMACOKINET E HANOVER NJ 07936
Titolo Testata:
Biopharmaceutics & drug disposition
fascicolo: 2, volume: 16, anno: 1995,
pagine: 137 - 150
SICI:
0142-2782(1995)16:2<137:TEOTFO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-PRODUCTION; INHIBITION; INSULIN; ACIDS;
Keywords:
FOOD; FAT; PHARMACOKINETICS; PHARMACODYNAMICS; DIABETES; DOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
D.T.W. Lau et al., "THE EFFECT OF THE FAT-CONTENT OF FOOD ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF SDZ FOX-988, AN ANTIDIABETIC AGENT, IN THE DOG", Biopharmaceutics & drug disposition, 16(2), 1995, pp. 137-150

Abstract

SDZ FOX 988 (FOX 988) is being developed for the treatment of type IIdiabetes. The objective of this study was to examine the effect of the fat content of food on the pharmacokinetics and pharmacodynamics of FOX 988 following oral administration in the dog. In a randomized, cross-over design, four dogs received a single 10 mg kg(-1) dose of C-14-FOX 988 suspension concomitantly with food containing 10% fat or 40% fat, or with the 10% fat food at 4 h post-dose. Serial blood, urine, and fecal samples were collected for 96 h and analyzed for total radioactivity. Blood concentrations of 53-450, the active metabolite of FOX 988, were also determined. Serum concentrations of beta-hydroxybutyrateand glucose, pharmacological markers for the antidiabetic effects, were measured serially for 24 h after dosing. The animals receiving the low-fat meal at dosing and at 4h post-dose exhibited similar extents of absorption, as shown by similar AUC values and urinary radioactivityrecovery. Administration of the high-fat meal at dosing significantlyenhanced the absorption of FOX 988 and resulted in high blood concentrations of 53-450. However, no significant differences in the pharmacological activity of the drug were observed among the three treatments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:16:51