Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE N-OXIDATION OF TRIMETHYLAMINE IN A JORDANIAN POPULATION
Autore:
HADIDI HF; CHOLERTON S; ATKINSON S; IRSHAID YM; RAWASHDEH NM; IDLE JR;
Indirizzi:
UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT PHARMACOL SCI,PHARMACOGENET RESUNIT NEWCASTLE TYNE NE2 4HH TYNE & WEAR ENGLAND UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT PHARMACOL SCI,PHARMACOGENET RESUNIT NEWCASTLE TYNE NE2 4HH TYNE & WEAR ENGLAND JORDAN UNIV SCI & TECHNOL,FAC MED,DEPT PHARMACOL IRBID JORDAN
Titolo Testata:
British journal of clinical pharmacology
fascicolo: 2, volume: 39, anno: 1995,
pagine: 179 - 181
SICI:
0306-5251(1995)39:2<179:TNOTIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-POLYMORPHISM;
Keywords:
TRIMETHYLAMINE; N-OXIDATION; JORDANIAN;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
H.F. Hadidi et al., "THE N-OXIDATION OF TRIMETHYLAMINE IN A JORDANIAN POPULATION", British journal of clinical pharmacology, 39(2), 1995, pp. 179-181

Abstract

The ability to oxidise trimethylamine (TMA) to trimethylamine N-oxide(TMAO) is distributed polymorphically within a British white population with the majority of individuals excreting greater than 90% of total urinary TMA as TMAO. The opposite extreme is characterised by a rareinborn error of TMA N-oxidation known as the fish-odour syndrome. However there is a lack of information regarding inter-individual variability in the N-oxidation of TMA in other ethnic groups. In this study the urinary excretion of TMA and TMAO was determined over a period of 24 h in 82 Jordanian subjects. A frequency distribution histogram of % of total urinary TMA excreted as TMAO revealed that the majority of subjects excreted greater than 80% of the total urinary TMA as TMAO, however eight subjects (9.7%) excreted less than 80% of the total TMA as TMAO. In a previous study of 169 white British subjects only one (0.6%) excreted less than 80% of the total TMA as TMAO. The results suggestthat the prevalence of compromised ability to N-oxidise TMA may be higher in a Jordanian population than in a British population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:10:05