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Titolo:
TRANSPLANTS TO THE CEREBRAL-CORTEX OF NUCLEUS BASALIS MAGNOCELLULARIS-LESIONED RATS - EFFECTS ON DEFICITS IN LATENT INHIBITION
Autore:
WELNER SA; ROUSSE I; ROCHFORD J;
Indirizzi:
MCGILL UNIV,DOUGLAS HOSP,RES CTR,DEPT PSYCHIAT,6875 BOUL LA SALLE MONTREAL PQ H4H 1R3 CANADA
Titolo Testata:
Brain research
fascicolo: 2, volume: 671, anno: 1995,
pagine: 309 - 313
SICI:
0006-8993(1995)671:2<309:TTTCON>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMORY IMPAIRMENTS; CHOLINE-ACETYLTRANSFERASE; NEURAL TRANSPLANTATION; FOREBRAIN LESIONS; SPATIAL MEMORY; ACID LESIONS; NEOCORTEX; NEURONS; GRAFTS; SENSORIMOTOR;
Keywords:
NUCLEUS BASALIS MAGNOCELLULARIS LESION; CHROMAFFIN CELL TRANSPLANT; SELECTIVE ATTENTION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Welner et al., "TRANSPLANTS TO THE CEREBRAL-CORTEX OF NUCLEUS BASALIS MAGNOCELLULARIS-LESIONED RATS - EFFECTS ON DEFICITS IN LATENT INHIBITION", Brain research, 671(2), 1995, pp. 309-313

Abstract

Bilateral quisqualic acid-induced lesions of the nucleus basalis magnocellularis (nbm) in rats disrupted the expression of latent inhibition, a phenomenon thought to be dependent upon selective attention processes. Since grafts of adrenal chromaffin cells to the cerebral cortex of nbm-lesioned rats have been shown to ameliorate other lesion-induced cognitive deficits, we tested here whether expression of latent inhibition could be reinstated by graft placement. Interestingly, grafts of either chromaffin cells or cells from kidney or liver that have beenused previously as control grafts, were able to restore latent inhibition in lesioned animals. These results suggest that it may be a host response to graft placement rather than a factor supplied by the grafted tissue itself that is responsible for the amelioration of lesion-induced deficits of latent inhibition.

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Documento generato il 07/07/20 alle ore 15:06:26